Signal transduction of erythrocytes after specific binding of ecdysterone and cholesterol immobilized on nanodispersed magnetite

Concurrent binding of cholesterol and ecdysterone immobilized on nanodispersed magnetite to intact rat erythrocytes was investigated. Several binding components on erythrocyte plasma membrane with different affinities were revealed in the range of 10 −15–10 −8 M. The specific binding modulates signa...

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Bibliographic Details
Published in:Journal of magnetism and magnetic materials 2001, Vol.225 (1), p.226-234
Main Authors: Mykhaylyk, O.M, Kotzuruba, A.V, Buchanevich, O.M, Korduban, A.M, Meged, E.F, Gulaya, N.M
Format: Article
Language:English
Subjects:
Biological and medical sciences
cAMP
Cell physiology
cGMP
Cholesterol
Ecdysterone
Erythrocyte
Fundamental and applied biological sciences. Psychology
Immobilization
Membrane effects
Molecular and cellular biology
Nanodispersed magnetite
Signal transduction
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Summary:Concurrent binding of cholesterol and ecdysterone immobilized on nanodispersed magnetite to intact rat erythrocytes was investigated. Several binding components on erythrocyte plasma membrane with different affinities were revealed in the range of 10 −15–10 −8 M. The specific binding modulates signal transduction through adenylate cyclase and guanylate cyclase systems as manifested by the decrease in cAMP and increase in cGMP second messenger production.
ISSN:0304-8853
DOI:10.1016/S0304-8853(00)01262-2