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A hemicyanidin-based NIR fluorescent probe for detection of H2S and imaging study in cells and mice
The selective detection of hydrogen sulfide in physiological and pathological processes has gained substantial attention in recent years. However, the real-time detection of hydrogen sulfide remains an elusive goal. In this work, a new type of hemicyanidin-based fluorescent “turn-on” probe NTR-HS (E...
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| Published in: | Mikrochimica acta (1966) 2022-08, Vol.189 (8), p.291-291, Article 291 |
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| Main Authors: | , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c352t-932a182458cb027a609eb2ac2dbee0caf931ddffe4a2efa92928ae3149a2aa5f3 |
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| cites | cdi_FETCH-LOGICAL-c352t-932a182458cb027a609eb2ac2dbee0caf931ddffe4a2efa92928ae3149a2aa5f3 |
| container_end_page | 291 |
| container_issue | 8 |
| container_start_page | 291 |
| container_title | Mikrochimica acta (1966) |
| container_volume | 189 |
| creator | Li, Bai Wang, Minghui Gu, Xin Chen, Jiajia Yang, Xindi Liu, Xuejin Xu, Kuoxi |
| description | The selective detection of hydrogen sulfide in physiological and pathological processes has gained substantial attention in recent years. However, the real-time detection of hydrogen sulfide remains an elusive goal. In this work, a new type of hemicyanidin-based fluorescent “turn-on” probe NTR-HS (Ex = 680 nm, Em = 760 nm) was developed to detected H
2
S in a very short time (3 min). The fluorescence quantum yield is 0.15 and accompanied with a noticeable color change from violet to blue that can be used to detect H
2
S in the range 1.04 × 10
−7
–4 × 10
−5
M with a limit of detection of 1.04 x 10
-7
M. The NTR-HS probe was also used for imaging of endogenous hydrogen sulfide and mitochondrial localization in HCT116 and HeLa cells. The detection mechanism was studied through fluorescence, UV–Vis, NMR, and mass analysis. Notably, the probe was successfully used to imaging H
2
S in mice and locating hydrogen sulfide in the large intestine of mice.
Graphical abstract |
| doi_str_mv | 10.1007/s00604-022-05374-7 |
| format | article |
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2
S in a very short time (3 min). The fluorescence quantum yield is 0.15 and accompanied with a noticeable color change from violet to blue that can be used to detect H
2
S in the range 1.04 × 10
−7
–4 × 10
−5
M with a limit of detection of 1.04 x 10
-7
M. The NTR-HS probe was also used for imaging of endogenous hydrogen sulfide and mitochondrial localization in HCT116 and HeLa cells. The detection mechanism was studied through fluorescence, UV–Vis, NMR, and mass analysis. Notably, the probe was successfully used to imaging H
2
S in mice and locating hydrogen sulfide in the large intestine of mice.
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2
S in a very short time (3 min). The fluorescence quantum yield is 0.15 and accompanied with a noticeable color change from violet to blue that can be used to detect H
2
S in the range 1.04 × 10
−7
–4 × 10
−5
M with a limit of detection of 1.04 x 10
-7
M. The NTR-HS probe was also used for imaging of endogenous hydrogen sulfide and mitochondrial localization in HCT116 and HeLa cells. The detection mechanism was studied through fluorescence, UV–Vis, NMR, and mass analysis. Notably, the probe was successfully used to imaging H
2
S in mice and locating hydrogen sulfide in the large intestine of mice.
Graphical abstract</description><subject>Analytical Chemistry</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Fluorescent indicators</subject><subject>Hydrogen sulfide</subject><subject>Imaging</subject><subject>Intestine</subject><subject>Microengineering</subject><subject>Nanochemistry</subject><subject>Nanotechnology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Original Paper</subject><issn>0026-3672</issn><issn>1436-5073</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kMFOGzEURa0KpKbAD3RliU03Ls_PnnG8RKgtSKiVWlhbHs9zOlHiAXtmkb_HSZCQWLDy4p17dX0Y-yrhuwQwVwWgBS0AUUCjjBbmE1tIrVrRgFEnbAGArVCtwc_sSylrAGla1AsWrvl_2g5h59PQD0l0vlDPf9_95XEzj5lKoDTxpzx2xOOYeU8ThWkYEx8jv8V_3KeeD1u_GtKKl2nud3xIPNBmUw6nWk3n7DT6TaGL1_eMPf788XBzK-7__Lq7ub4XQTU4CavQyyXqZhk6QONbsNShD9h3RBB8tEr2fYykPVL0Fi0uPSmprUfvm6jO2Ldjb537PFOZ3HYo-yk-0TgXh63VtrGqlRW9fIeuxzmnuu5A6cYALiuFRyrksZRM0T3l-te8cxLc3rs7enfVuzt4d6aG1DFUKpxWlN-qP0i9ADRdhVY</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Li, Bai</creator><creator>Wang, Minghui</creator><creator>Gu, Xin</creator><creator>Chen, Jiajia</creator><creator>Yang, Xindi</creator><creator>Liu, Xuejin</creator><creator>Xu, Kuoxi</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20220801</creationdate><title>A hemicyanidin-based NIR fluorescent probe for detection of H2S and imaging study in cells and mice</title><author>Li, Bai ; Wang, Minghui ; Gu, Xin ; Chen, Jiajia ; Yang, Xindi ; Liu, Xuejin ; Xu, Kuoxi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-932a182458cb027a609eb2ac2dbee0caf931ddffe4a2efa92928ae3149a2aa5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analytical Chemistry</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Fluorescent indicators</topic><topic>Hydrogen sulfide</topic><topic>Imaging</topic><topic>Intestine</topic><topic>Microengineering</topic><topic>Nanochemistry</topic><topic>Nanotechnology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Original Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Bai</creatorcontrib><creatorcontrib>Wang, Minghui</creatorcontrib><creatorcontrib>Gu, Xin</creatorcontrib><creatorcontrib>Chen, Jiajia</creatorcontrib><creatorcontrib>Yang, Xindi</creatorcontrib><creatorcontrib>Liu, Xuejin</creatorcontrib><creatorcontrib>Xu, Kuoxi</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Mikrochimica acta (1966)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Bai</au><au>Wang, Minghui</au><au>Gu, Xin</au><au>Chen, Jiajia</au><au>Yang, Xindi</au><au>Liu, Xuejin</au><au>Xu, Kuoxi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A hemicyanidin-based NIR fluorescent probe for detection of H2S and imaging study in cells and mice</atitle><jtitle>Mikrochimica acta (1966)</jtitle><stitle>Microchim Acta</stitle><date>2022-08-01</date><risdate>2022</risdate><volume>189</volume><issue>8</issue><spage>291</spage><epage>291</epage><pages>291-291</pages><artnum>291</artnum><issn>0026-3672</issn><eissn>1436-5073</eissn><abstract>The selective detection of hydrogen sulfide in physiological and pathological processes has gained substantial attention in recent years. However, the real-time detection of hydrogen sulfide remains an elusive goal. In this work, a new type of hemicyanidin-based fluorescent “turn-on” probe NTR-HS (Ex = 680 nm, Em = 760 nm) was developed to detected H
2
S in a very short time (3 min). The fluorescence quantum yield is 0.15 and accompanied with a noticeable color change from violet to blue that can be used to detect H
2
S in the range 1.04 × 10
−7
–4 × 10
−5
M with a limit of detection of 1.04 x 10
-7
M. The NTR-HS probe was also used for imaging of endogenous hydrogen sulfide and mitochondrial localization in HCT116 and HeLa cells. The detection mechanism was studied through fluorescence, UV–Vis, NMR, and mass analysis. Notably, the probe was successfully used to imaging H
2
S in mice and locating hydrogen sulfide in the large intestine of mice.
Graphical abstract</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><doi>10.1007/s00604-022-05374-7</doi><tpages>1</tpages></addata></record> |
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| issn | 0026-3672 1436-5073 |
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| subjects | Analytical Chemistry Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Fluorescent indicators Hydrogen sulfide Imaging Intestine Microengineering Nanochemistry Nanotechnology NMR Nuclear magnetic resonance Original Paper |
| title | A hemicyanidin-based NIR fluorescent probe for detection of H2S and imaging study in cells and mice |
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