Patient-, Provider-, and System-Level Barriers to Surveillance for Hepatocellular Carcinoma in High-Risk Patients in the USA: a Scoping Review

• Published in: Journal of gastrointestinal cancer 2023-06, Vol.54 (2), p.332-356
• Main Authors: Beal, Eliza W., Owen, Mackenzie, McNamara, Molly, McAlearney, Ann Scheck, Tsung, Allan
• Format: Article
• Language: English
• Subjects: Cancer Research; Gastroenterology; Internal Medicine; Medicine; Medicine & Public Health; Oncology; Radiotherapy; Review
• ISSN: 1941-6628; 1941-6636
• DOI: 10.1007/s12029-022-00851-x

Purpose Hepatocellular carcinoma has a dismal prognosis, except in patients diagnosed early who are candidates for potentially curative therapies. Most HCC cases develop in patients with chronic liver disease. Therefore, expert society guidelines recommend surveillance every 6 months with ultrasound with or without serum alpha-fetoprotein for high-risk patients. However, fewer than 20% of patients in the USA undergo appropriate surveillance. Methods A systematic scoping review was performed with the objective of identifying barriers to screening among high-risk patients in the USA including mapping key concepts in the relevant literature, identifying the main sources and types of evidence available, and identifying gaps in the literature. A total of 43 studies published from 2007 to 2021 were included. Data were extracted and a conceptual framework was created. Results Assessment of quantitative studies revealed poor surveillance rates, often below 50%. Three categories of barriers to surveillance were identified: patient-level, provider-level, and system-level barriers. Prevalent patient-level barriers included financial constraints, lack of awareness of surveillance recommendations, and scheduling difficulties. Common provider-level barriers were lack of provider awareness of guidelines for surveillance, difficulty accessing specialty resources, and time constraints in the clinic. System-level barriers included fewer clinic visits and rural/safety-net settings. Proposed interventions include improved patient/provider education, patient navigators, increased community/academic collaboration, and EMR-based reminders. Conclusion Based on these findings, there is a crucial need to implement and evaluate proposed interventions to improve HCC surveillance.