Relationship Between Hypovitaminosis D and Fractures Among Adolescents With Overweight or Obesity

• Published in: Clinical pediatrics 2023-02, Vol.62 (2), p.107-114
• Main Authors: Segal, David, Ziv, Adi, Meisman, Andrea, Fry, Jordan, Altaye, Mekibib, Gordon, Catherine M.
• Format: Article
• Language: English
• Subjects: 25-Hydroxyvitamin D; Adolescent; Adolescents; Body Mass Index; Body weight; Case-Control Studies; Female; Fractures; Fractures, Bone - complications; Fractures, Bone - etiology; Humans; Male; Obesity; Obesity - complications; Obesity - epidemiology; Overweight; Overweight - complications; Overweight - epidemiology; Pediatrics; Retrospective Studies; Rickets; Teenagers; Vitamin D; Vitamin D Deficiency - complications; Vitamin D Deficiency - epidemiology; Vitamin deficiency
• ISSN: 0009-9228; 1938-2707
• DOI: 10.1177/00099228221112461

Adolescents with overweight/obesity are at risk for vitamin D insufficiency and deficiency. Both overweight/obesity and vitamin D insufficiency/deficiency may predispose to fractures. We enrolled 103 participants (53.3% females, 15.9 ± 2.2 years) in a retrospective case-control study to determine whether an association exists between fractures and a low 25-hydroxyvitamin D (25[OH]D) among adolescents whose body mass index (BMI) ≥ 85 percentile. Cases (n = 28) sustaining a low/medium impact fracture were matched to controls (n = 75) without a fracture history. A conditional-logistic regression analysis addressing the common vitamin D insufficiency/deficiency cutoffs was used. Overweight, obesity, and significant obesity rates were 10.7%, 53.4%, and 35.9%, respectively. Mean (±SD) 25(OH)D was 16.5 ± 6.4 ng/mL. In all, 25(OH)D insufficiency rates (level .05). Controlling for race and seasonality showed no association between fractures and 25(OH)D insufficiency/deficiency (P > .05). These data suggest that fractures are not associated with low 25(OH)D levels among adolescents whose BMI ≥ 85th percentile.