Late outcomes in children and adolescents with non-Hodgkin lymphoma: A single-center experience

Background: Non-Hodgkin lymphoma (NHL) includes pathologies of different clinical courses, treatments, outcomes. Our study aims to investigate the late effects of NHL survivors (NHLS). Materials and Methods: Among 59 NHL cases, 50 survivors completed their NHL treatment between 2003 and 2019. Out of...

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Published in:Journal of cancer research and therapeutics 2022-07, Vol.18 (3), p.712-717
Main Authors: Tacyildiz, Nurdan, Çakmak, Hatice, Ünal, Emel, Dinçaslan, Handan, Yılmaz, Yasin, Kartal, Ömer, Tanyıldız, Gülşah, Özdemir, Sonay, Yavuz, Gülsan
Format: Article
Language:English
Subjects:
Cancer in children
Cardiotoxicity
Care and treatment
Lymphoma
Non-Hodgkin's lymphomas
Patient outcomes
Pediatric research
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Summary:Background: Non-Hodgkin lymphoma (NHL) includes pathologies of different clinical courses, treatments, outcomes. Our study aims to investigate the late effects of NHL survivors (NHLS). Materials and Methods: Among 59 NHL cases, 50 survivors completed their NHL treatment between 2003 and 2019. Out of 59 patients, the cumulative survival rates and event-free survival rates after 10 years since diagnosis were 82.9% ±5.2% and 84.1% ±5.2%, respectively. In addition, we compared the data related to chronic health and psychosocial conditions with their siblings (n = 61). Results: The age and gender ratios were similar in the NHLS (n = 50) and the control group (n = 61). The rate of nephrotoxicity (P = 0.02) and the frequency of admission to the hospital (P < 0.01) were significantly higher in the survivors than in the control group. Cardiotoxicity is detected in 3 (6%) of NHLS with cumulative anthracycline dose
ISSN:0973-1482
1998-4138
DOI:10.4103/jcrt.jcrt_80_21