Palladium-Catalyzed Regioselective Intermolecular Hydroalkoxylation of 1‑Arylbutadienes

An efficient method for the synthesis of (E)-(3-alkoxybut-1-enyl)­benzenes by Pd-catalyzed regioselective intermolecular hydroalkoxylation of 1-arylbutadienes has been developed. This method can be executed in a simple operation with no dry reaction conditions required and having tolerance to a wide...

Full description

Saved in:
Bibliographic Details
Published in:Journal of organic chemistry 2023-08, Vol.88 (15), p.10339-10354
Main Authors: Fernandes, Rodney A., Chandra, Naveen, Gangani, Ashvin J., Khatun, Gulenur N.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An efficient method for the synthesis of (E)-(3-alkoxybut-1-enyl)­benzenes by Pd-catalyzed regioselective intermolecular hydroalkoxylation of 1-arylbutadienes has been developed. This method can be executed in a simple operation with no dry reaction conditions required and having tolerance to a wide range of substrates. Chloromethyl methyl ether (MOMCl) as an additive was found to be essential for the success of the reaction.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.2c01252