Autoimmune atrophic gastritis and coeliac disease: A case-control study

Autoimmune atrophic gastritis (AAG) is rarely associated with coeliac disease (CD). To assess the frequency of AAG-CD association and to compare clinical, biochemical, and histological features of adults affected by both diseases (cases) with AAG controls. This case-control study included 9 cases (F...

Full description

Saved in:
Bibliographic Details
Published in:Digestive and liver disease 2023-01, Vol.55 (1), p.69-74
Main Authors: Conti, Laura, Galli, Gloria, Ligato, Chiara, Carabotti, Marilia, Annibale, Bruno, Lahner, Edith
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Atrophic gastritis
Atrophy
Autoimmune Diseases - complications
Autoimmune Diseases - epidemiology
Autoimmune gastritis
Case-Control Studies
Celiac Disease - complications
Celiac Disease - diagnosis
Celiac Disease - epidemiology
Coeliac disease
Female
Gastritis - complications
Gastritis, Atrophic - diagnosis
Humans
Male
Middle Aged
Pernicious anaemia
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Autoimmune atrophic gastritis (AAG) is rarely associated with coeliac disease (CD). To assess the frequency of AAG-CD association and to compare clinical, biochemical, and histological features of adults affected by both diseases (cases) with AAG controls. This case-control study included 9 cases (F55%, median age 47, range 23–59yrs) matched (1:3) by age (±4 yrs) and gender to 27 controls randomly selected from our AAG cohort (2009–2021). The AAG and CD diagnosis was based on internationally agreed criteria. Of 434 AAG patients (median age:62.5yrs, range18–92yrs, F:M ratio=2.2:1),9 had a concomitant diagnosis of CD. The occurrence of AAG-CD association was 2% and 1.65% among AAG/CD cohorts, respectively. Cases were significantly younger than AAG cohort (n = 425, p = 0.002). In 4/9cases, AAG was diagnosed by proactive screening for autoimmune disorders. Autoimmune thyroid disorders were present in 5/9 cases. Cases had a significant higher prevalence of normocytic anaemia than controls (p = 0.004). No significant differences were found between cases and controls concerning clinical and histological features. AAG-CD association is rare. Gastric and duodenal biopsies might be advisable in young people with normocytic anaemia and associated autoimmune disorders to timely diagnose clinically silent conditions.
ISSN:1590-8658
1878-3562
DOI:10.1016/j.dld.2022.07.001