Review old bone, new tricks

Despite the significant progress made over the past decade with combination of molecular profiling data and the development of new clinical strategies, our understanding of metastasis remains elusive. Bone metastasis is a complex process and a major cause of mortality in breast and prostate cancer p...

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Bibliographic Details
Published in:Clinical & experimental metastasis 2022-10, Vol.39 (5), p.727-742
Main Authors: Barsky, Livnat, Cohen-Erez, Ifat, Bado, Igor, Zhang, Xiang H-F, Vago, Razi
Format: Article
Language:English
Subjects:
Angiogenesis
Biomedical and Life Sciences
Biomedicine
Bones
Breast cancer
Cancer Research
Cell adhesion
Collagen
Dormancy
Gene expression
Hematology
Homeostasis
Hydroxyapatite
Medical prognosis
Melanoma
Metastases
Metastasis
Microenvironments
Mineralization
Morphology
Oncology
Prostate
Prostate cancer
Review
Surgical Oncology
Thyroid gland
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Summary:Despite the significant progress made over the past decade with combination of molecular profiling data and the development of new clinical strategies, our understanding of metastasis remains elusive. Bone metastasis is a complex process and a major cause of mortality in breast and prostate cancer patients, for which there is no effective treatment to-date. The current review summarizes the routes taken by the metastatic cells and the interactions between them and the bone microenvironment. We emphasize the role of the specified niches and cues that promote cellular adhesion, colonization, prolonged dormancy, and reactivation. Understanding these mechanisms will provide better insights for future studies and treatment strategies for bone metastatic conditions.
ISSN:0262-0898
1573-7276
DOI:10.1007/s10585-022-10176-5