Malignant rhabdoid tumor: Cyto-histologic correlation and immunohistochemical characterization of a rare pediatric malignancy and its differential diagnoses

Malignant rhabdoid tumor of the kidney (MRTK) is a rare aggressive pediatric renal tumor which can be diagnosed via fine-needle aspiration (FNA) cytology and core biopsy. The diagnosis of MRTK is challenging, and requires morphologic, immunohistochemical and clinical correlation to distinguish it fr...

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Bibliographic Details
Published in:Annals of diagnostic pathology 2022-10, Vol.60, p.152014-152014, Article 152014
Main Authors: Kerper, Allison L., Clarke-Brodber, Anna-Lee, Gupta, Sounak, Whalen, Kirsten M., Nigdelioglu, Recep, Boland, Jennifer M., Schembri Wismayer, David J., Torres-Mora, Jorge, Mejia Acevedo, Marco R., Sudhindran, Vineeth, Sturgis, Charles D.
Format: Article
Language:English
Subjects:
INI-1
Malignant rhabdoid tumor
MRTK
Pediatric renal mass
SMARCB1
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Summary:Malignant rhabdoid tumor of the kidney (MRTK) is a rare aggressive pediatric renal tumor which can be diagnosed via fine-needle aspiration (FNA) cytology and core biopsy. The diagnosis of MRTK is challenging, and requires morphologic, immunohistochemical and clinical correlation to distinguish it from other entities. The differential diagnosis includes Wilms tumor, desmoplastic small round cell tumor, rhabdomyosarcoma, synovial sarcoma, renal medullary carcinoma, and epithelioid sarcoma. Here we describe a case of MRTK diagnosed on renal cytology and core biopsy with immunohistochemistry and follow by nephrectomy with gross and morphologic findings. •Malignant rhabdoid tumor of the kidney (MRTK) is a rare pediatric malignancy.•Several pediatric renal tumors have overlapping morphologic characteristics.•MRTK is characterized by complete loss of INI-1 expression by immunohistochemistry.•MRTK can be diagnosed on a small biopsy using morphology and immunohistochemistry.
ISSN:1092-9134
1532-8198
DOI:10.1016/j.anndiagpath.2022.152014