Effect of refractive status on retinal nerve fiber layer thickness in Chinese Population

Purpose To evaluate the relationship between retinal nerve fiber layer (RNFL) thickness and other related parameters measured by spectral-domain optical coherence tomography and the refractive error of eyes. Methods A total of 5394 subjects were enrolled in this population-based cohort study, who we...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2023, Vol.261 (1), p.201-211
Main Authors: Wu, Jian, Du, Yifan, Lin, Caixia, Du, Jianli, Chen, Wei, Ji, Qian Qian, Wang, Ningli
Format: Article
Language:English
Subjects:
Adult
Cohort Studies
Cornea
East Asian People
Glaucoma
Humans
Medicine
Medicine & Public Health
Middle Aged
Myopia
Myopia - diagnosis
Nerve Fibers
Ophthalmology
Population studies
Refractive Errors - diagnosis
Retina
Retinal Ganglion Cells
Statistical analysis
Tomography, Optical Coherence - methods
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Summary:Purpose To evaluate the relationship between retinal nerve fiber layer (RNFL) thickness and other related parameters measured by spectral-domain optical coherence tomography and the refractive error of eyes. Methods A total of 5394 subjects were enrolled in this population-based cohort study, who were divided into three groups by refractive state after they underwent a standardized ophthalmic examination: emmetropia (the absolute value should range from 0 to 0.5 D), low-moderate myopia (the absolute value of myopic error should range from 0.5 to 6 D), and high myopia (the absolute value of myopic error should be over than 6 D). R 3.6.1 software was adopted for statistical analysis. Results Two thousand five hundred fifty-two subjects (4548 eyes) were collected in this study, with an average age of 53.14 ± 10.64 years. There were significant differences among groups in average central corneal curvature, spherical equivalent, and axial length ( P  
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-022-05753-z