Superficial versus total parotidectomy for metastatic cutaneous squamous cell carcinoma and melanoma of the head and neck: a systematic review

The extent of parotidectomy in the management of regional metastatic disease is controversial. This systematic review aimed to appraise data from studies evaluating superficial and total parotidectomy in metastatic cutaneous squamous cell carcinoma and cutaneous malignant melanoma of the head and ne...

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Bibliographic Details
Published in:Journal of laryngology and otology 2023-06, Vol.137 (6), p.592-598
Main Authors: Leong, W S, Gowda, S, Jackson, R, Chabrillac, E, Edafe, O
Format: Article
Language:English
Subjects:
Carcinoma, Squamous Cell
Chemotherapy
Dissection
Exocrine glands
Head and neck
Histology
Humans
Lymphatic system
Melanoma
Melanoma - surgery
Melanoma, Cutaneous Malignant
Metastases
Metastasis
Morbidity
Neck
Neoplasm Recurrence, Local - epidemiology
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Oral cancer
Parotid gland
Parotid Gland - pathology
Parotid Gland - surgery
Parotid Neoplasms - pathology
Parotid Neoplasms - surgery
Quality of life
Radiation therapy
Retrospective Studies
Reviews
Skin cancer
Skin Neoplasms - pathology
Skin Neoplasms - surgery
Squamous cell carcinoma
Systematic review
Wound healing
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Summary:The extent of parotidectomy in the management of regional metastatic disease is controversial. This systematic review aimed to appraise data from studies evaluating superficial and total parotidectomy in metastatic cutaneous squamous cell carcinoma and cutaneous malignant melanoma of the head and neck. A systematic search of PubMed, Embase and Cochrane Library was performed. The protocol was registered with Prospero (CRD42020217962). A total of five studies evaluated cutaneous malignant melanoma. Only one compared outcomes of superficial and total parotidectomy: they found higher parotid area recurrence following superficial parotidectomy. Seven studies reported outcomes following cutaneous squamous cell carcinoma; some studies found higher regional recurrence and reduced survival in total parotidectomy, but there was likely selection bias in these studies. Others found no difference in survival between superficial and total parotidectomy. The effect of the extent of parotidectomy on outcomes is unclear in cutaneous malignant melanoma and cutaneous squamous cell carcinoma. This systematic review highlights the need for well-designed studies to direct better care.
ISSN:0022-2151
1748-5460
DOI:10.1017/S0022215122001724