Lhermitte-Duclos disease (dysplastic cerebellar gangliocytoma) in the setting of cowden syndrome: a case report and literature review on COLD syndrome

• Published in: British journal of neurosurgery 2024-10, Vol.38 (5), p.1170-4
• Main Authors: McMahon, M E, Murray, D, MacNally, S, O'Brien, D F
• Format: Article
• Language: English
• Subjects: Cerebellar Neoplasms - complications; Cerebellar Neoplasms - diagnostic imaging; Cerebellar Neoplasms - genetics; Cerebellar Neoplasms - pathology; Cerebellar Neoplasms - surgery; Female; Ganglioneuroma - complications; Ganglioneuroma - diagnosis; Ganglioneuroma - genetics; Ganglioneuroma - pathology; Ganglioneuroma - surgery; Hamartoma Syndrome, Multiple - complications; Hamartoma Syndrome, Multiple - diagnosis; Hamartoma Syndrome, Multiple - genetics; Hamartoma Syndrome, Multiple - pathology; Hamartoma Syndrome, Multiple - surgery; Humans; Magnetic Resonance Imaging; Middle Aged; PTEN Phosphohydrolase - genetics
• ISSN: 0268-8697; 1360-046X; 1360-046X
• DOI: 10.1080/02688697.2022.2106354

Lhermitte-Duclos Disease is a rare clinical entity involving a dysplastic lesion of the cerebellum. The dysplastic cerebellar ganglioblastoma is often seen in association with Cowden Syndrome, an autosomal dominant disorder consisting of a mutation in the phosphatase and homologous tensin (PTEN) gene. Characteristic findings on neuroimaging allow for a pre-operative diagnosis to be made, which guides further management of the condition. This report describes the diagnosis and management of Lhermitte-Duclos Disease in a 51-year-old lady, spanning a period of almost seven years. The characteristic radiological and histological findings are presented, along with the clinical features associated with Cowden Syndrome. This patient ultimately underwent surgical intervention for symptomatic relief, which is described here.