A pathway of osmotic stress-induced necroptosis

Necroptosis is a form of regulated necrosis in which RIPK3 is activated by binding to RIP homotypic interaction motif (RHIM)-containing proteins. Now, researchers describe a non-canonical pathway of RIPK3 activation that is triggered by osmotic stress and NHE1-mediated cytosol alkalinization. This p...

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Bibliographic Details
Published in:Nature reviews. Nephrology 2022-10, Vol.18 (10), p.609-610
Main Authors: Ortiz, Alberto, Sanz, Ana B.
Format: Article
Language:English
Subjects:
631/80/82
692/699
Apoptosis
Cancer
Hypernatremia
Kidneys
Kinases
Medicine
Medicine & Public Health
Nephrology
News & Views
news-and-views
Osmosis
Proteins
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Summary:Necroptosis is a form of regulated necrosis in which RIPK3 is activated by binding to RIP homotypic interaction motif (RHIM)-containing proteins. Now, researchers describe a non-canonical pathway of RIPK3 activation that is triggered by osmotic stress and NHE1-mediated cytosol alkalinization. This previously undescribed mechanism of osmotic stress-induced necroptosis might have implications for treating cancer and other diseases.
ISSN:1759-5061
1759-507X
DOI:10.1038/s41581-022-00607-7