The importance of regulatory pathway mediated by Circ0001955 in colorectal cancer

Colorectal cancer (CRC) has become one of the most common cancers in recent years. Given the importance that non-coding RNAs have recently acquired in various diseases including cancers, we decided to design this study to evaluate the expression levels of circ0001955/miR-145-5p/ONECUT2 axis in CRC....

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Published in:Experimental and molecular pathology 2022-10, Vol.128, p.104819-104819, Article 104819
Main Authors: Kadkhoda, Sepideh, Ghafouri-Fard, Soudeh, Noorbakhsh, Farshid, Ravaei, Sima, Darbeheshti, Farzaneh, Amoli, Mahsa M., Taslimi, Reza, Shakoori, Abbas
Format: Article
Language:English
Subjects:
Cell Proliferation
Circ0001955
Colorectal Cancer (CRC)
Colorectal Neoplasms - pathology
Gene Expression Regulation, Neoplastic - genetics
GEO dataset
Homeodomain Proteins - genetics
Humans
MicroRNAs - genetics
MicroRNAs - metabolism
miR-145-5p
ONECUT2
Transcription Factors - genetics
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Summary:Colorectal cancer (CRC) has become one of the most common cancers in recent years. Given the importance that non-coding RNAs have recently acquired in various diseases including cancers, we decided to design this study to evaluate the expression levels of circ0001955/miR-145-5p/ONECUT2 axis in CRC. After bioinformatics analysis of GEO datasets related to CRC, a putative circ0001955/ miR-145-5p/ ONECUT2 pathway was assumed. Then, the expression levels of these genes were measured in 50 CRC samples and adjacent tissues by qRT- PCR. Also, correlation coefficients, receiver operating characteristic (ROC) curves, and correlation between circ0001955 levels with clinicopathological parameters of patients were analyzed. Circ0001955 and ONECUT2 were considerably up-regulated, while the expression level of miR-145-5p was decreased in CRC samples compared with adjacent tissues (p 
ISSN:0014-4800
1096-0945
DOI:10.1016/j.yexmp.2022.104819