Outcomes of endoscopic submucosal dissection in patients who develop metachronous superficial esophageal squamous cell carcinoma close to a post-endoscopic submucosal dissection scar

• Published in: Esophagus : official journal of the Japan Esophageal Society 2023, Vol.20 (1), p.124-133
• Main Authors: Fukuhara, Motomitsu, Urabe, Yuji, Oka, Shiro, Mizuno, Jyunichi, Tanaka, Hidenori, Yamashita, Ken, Hiyama, Yuichi, Takigawa, Hidehiko, Kotachi, Takahiro, Yuge, Ryo, Arihiro, Koji, Tanaka, Shinji
• Format: Article
• Language: English
• Subjects: Cancer surgery; Cicatrix - etiology; Cicatrix - pathology; Dehydrogenases; Dissection; Endoscopic Mucosal Resection - adverse effects; Endoscopy; Esophageal cancer; Esophageal Neoplasms - pathology; Esophageal Squamous Cell Carcinoma - surgery; Gastroenterology; Humans; Iodine; Medicine; Medicine & Public Health; Metabolism; Original Article; Patients; Retrospective Studies; Squamous cell carcinoma; Surgical Oncology; Surgical outcomes; Thoracic Surgery
• ISSN: 1612-9059; 1612-9067
• DOI: 10.1007/s10388-022-00945-2

Background The presence of post-endoscopic submucosal dissection (ESD) scars renders complete metachronous superficial esophageal squamous cell carcinoma resection difficult. We aimed to identify the risk factors for incomplete resection of metachronous esophageal squamous cell carcinoma close to the post-ESD scar by ESD. Methods We enrolled patients who developed post-ESD superficial esophageal squamous cell carcinoma at Hiroshima University Hospital between January 2006 and March 2020. We analyzed the outcomes and risk factors of incomplete resection between patients whose lesions were close to (close-to group) and away from (away-from group) the post-ESD scar. Results We included 111 patients with 212 lesions. The close-to group had a significantly lower complete resection rate (88.6% [62/70] vs. 98.6% [69/70], p  = 0.033), longer procedure time (80.2 ± 47.2 min vs. 60.4 ± 29.3 min, p