Novel bioactive adhesive dressing based on gelatin/ chitosan cross-linked cactus mucilage for wound healing

The development of natural-based wound dressings is of great interest in the field of skin tissue engineering. Herein, different bioactive molecules such as gelatin (GEL), chitosan (CH) and mucilage (MU) were used to prepare a wound dressing. The physico-chemical and biological characterizations occ...

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Bibliographic Details
Published in:International journal of artificial organs 2022-10, Vol.45 (10), p.857-864
Main Authors: Jebahi, Samira, Salma, Bessaleh, Raouafi, Amel, Sawsen, Hajji, Hassib, Keskes, Hidouri, Mustpha
Format: Article
Language:English
Subjects:
Anti-inflammatory agents
Antibacterial activity
Biological activity
Biomaterials
Biomedical materials
Chitosan
Crosslinking
Electron paramagnetic resonance
Electron spin resonance
Fourier transforms
Functional groups
Gamma irradiation
Gamma rays
Gelatin
Inflammation
Infrared spectroscopy
Irradiation
Medical dressings
Mucilage
Polymers
Spectrum analysis
Tissue engineering
Wound healing
X-ray diffraction
γ Radiation
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Summary:The development of natural-based wound dressings is of great interest in the field of skin tissue engineering. Herein, different bioactive molecules such as gelatin (GEL), chitosan (CH) and mucilage (MU) were used to prepare a wound dressing. The physico-chemical and biological characterizations occurring after γ-irradiation were investigated. Results showed that Electron Paramagnetic Resonance (EPR) spectroscopy of un-irradiated GEL-CH-MU biomaterial showed two paramagnetic centers which correspond to g = 1.89 and g = 2.033. A generated new active center appeared at g = 2.003 at 25 kGy due to the interactions of gamma rays with the polymer chain creating signals at the absorbing functional groups. X-ray diffraction (XRD) spectra preserved the semi-crystalline structures between a range of 2θ (5° and 45°). Fourier Transform Infrared spectroscopy (FTIR) revealed that the initiation of cross linking phenomena. Moreover, γ-rays significantly increased antioxidant activity (9.1 ± 0.07%, p 
ISSN:0391-3988
1724-6040
DOI:10.1177/03913988221114158