Effective suppression of myocardial glucose uptake using predesigned low-carbohydrate boxed meals

• Published in: Journal of nuclear cardiology 2023-04, Vol.30 (2), p.484-494
• Main Authors: Huang, Cheng-Kai, Hou, Po-Nien, Luzhbin, Dmytro, Yang, Chao-Wei, Chang, Yu-Ting, Wu, Jay
• Format: Article
• Language: English
• Subjects: Animals; Carbohydrate restriction; Carbohydrates; Cardiology; Diet; Diet, Carbohydrate-Restricted; dietary preparation; FDG; Fluorodeoxyglucose F18; Glucose; Imaging; Meals; Medicine; Medicine & Public Health; Myocardium; Nuclear Medicine; Original Article; PET/CT; Physiology; preparación dietética; Radiology; Radiopharmaceuticals; restricción de carbohidratos
• ISSN: 1071-3581; 1532-6551
• DOI: 10.1007/s12350-022-03076-4

Dietary preparation protocols are an effective means to suppress physiological myocardial 18F-fluorodeoxyglucose (FDG) uptake. This study aimed to investigate the efficacy of various carbohydrate-restricted diets using predesigned boxed meals. The patients were divided into four groups to undergo different preparatory protocols as follows: a minimum 15-hour fast alone, two meals of high-fat, low-carbohydrate diet (HFLCD), two meals of high-animal-protein, low-carbohydrate diet (HAPLCD), and two meals of high-plant-based-protein, low-carbohydrate diet (HPPLCD). Boxed meals were prepared to meet the required carbohydrate restrictions. Myocardial SUVmax and SUVmean were measured and the suppression rate was analyzed. The average myocardial SUVmax of fast alone, HFLCD, HAPLCD, and HPPLCD were 8.26 ± 5.85, 2.21 ± 1.50, 2.34 ± 1.88, and 4.10 ± 3.61, respectively, and the suppression rates were 36.6%, 93.3%, 93.3%, and 70%, respectively. The effectiveness of HFLCD, HAPLCD, and HPPLCD was all statistically superior to that of a 15-hour fast alone. SUVmax of HFLCD and HAPLCD showed no significant differences (p = 1), whereas HFLCD and HPPLCD had significant differences (p = .046). Using the predesigned boxed meals based on carbohydrate restriction, HFLCD, HAPLCD, and HPPLCD can be administered to patients with different dietary needs while providing a substantial reduction in physiological myocardial FDG uptake. Los protocolos de preparación dietética son un medio eficaz para suprimir la captación fisiológica de 18F-fluorodesoxiglucosa (FDG) miocárdica. Este estudio tuvo como objetivo investigar la eficacia de varias dietas restringidas en carbohidratos utilizando comidas de cajas prediseñadas. Los pacientes se dividieron en cuatro grupos y se sometieron a diferentes protocolos de preparación de la siguiente manera: un mínimo de 15 horas de ayuno solo, dos comidas de una dieta rica en grasas y baja en carbohidratos (HFLCD), dos comidas de una dieta rica en proteínas animales y baja en carbohidratos. (HAPLCD) y dos comidas de una dieta alta en proteínas de origen vegetal y baja en carbohidratos (HPPLCD). Se prepararon comidas en cajas para cumplir con las restricciones de carbohidratos requeridas. Se midieron el SUVmax y el SUVmedio miocárdicos y se analizó la tasa de supresión. El SUVmax miocárdico promedio de ayuno solo, HFLCD, HAPLCD y HPPLCD fue 8.26 ± 5.85, 2.21 ± 1.50, 2.4 ± 1.88 y 4.10 ± 3.61, respectivamente, y la tasa de supresión fue 36.6%, 93.3%, 93.3% y