Two new dammarane triterpenoid saponins from the leaves of Cyclocarya paliurus

Two undescribed dammarane triterpenoid saponins, cypaliurusides O and P (1 and 2), were isolated from the ethanol extracts of the leaves of Cyclocarya paliurus. Bioactivity assay results showed that compound 1 has potential cytotoxic activities against selected human cancer cell lines in vitro, with...

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Bibliographic Details
Published in:Journal of asian natural products research 2023-05, Vol.25 (5), p.438-445
Main Authors: Li, Shan-Bin, Xian, Xiao-Ya, Peng, Cai-Feng, Chen, Li-Qun, Luo, Qin, Wang, Li-Sheng, Zhou, Xian-Li, Liang, Cheng-Qin
Format: Article
Language:English
Subjects:
Anticancer properties
Antitumor activity
Biological activity
Cell Line
Cyclocarya paliurus
cytotoxic activity
Cytotoxicity
dammarane triterpenoid saponin
Dammaranes
Ethanol
Humans
Juglandaceae
Plant Extracts
Plant Leaves
Saponins
Saponins - pharmacology
Triterpenes - pharmacology
Tumor cell lines
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Summary:Two undescribed dammarane triterpenoid saponins, cypaliurusides O and P (1 and 2), were isolated from the ethanol extracts of the leaves of Cyclocarya paliurus. Bioactivity assay results showed that compound 1 has potential cytotoxic activities against selected human cancer cell lines in vitro, with IC 50 values ranging from 14.55 ± 0.55 to 22.75 ± 1.54 µM. Compound 1 showed better antitumor activity against HepG2 cells with IC 50 of 14.55 ± 0.55 µM. In addition, compound 2 showed no obvious antitumor activity.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2022.2099384