Effects of Progesterone on Preclinical Animal Models of Traumatic Brain Injury: Systematic Review and Meta-analysis

Since the publication of two phase III clinical trials not supporting the use of progesterone in patients with traumatic brain injury (TBI), several possible explanations have been postulated, including limitations in the analysis of results from preclinical evidence. Therefore, to address this ques...

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Bibliographic Details
Published in:Molecular neurobiology 2022-10, Vol.59 (10), p.6341-6362
Main Authors: Nasre-Nasser, Raif Gregorio, Severo, Maria Manoela Rezende, Pires, Gabriel Natan, Hort, Mariana Appel, Arbo, Bruno Dutra
Format: Article
Language:English
Subjects:
Animal models
Animals
Biomedical and Life Sciences
Biomedicine
Brain Edema - drug therapy
Brain Injuries, Traumatic - drug therapy
Cell Biology
Clinical trials
Edema
Lesions
Meta-analysis
Models, Animal
Neurobiology
Neurology
Neuroprotection
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Neurosciences
Progesterone
Progesterone - pharmacology
Progesterone - therapeutic use
Systematic review
Traumatic brain injury
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Summary:Since the publication of two phase III clinical trials not supporting the use of progesterone in patients with traumatic brain injury (TBI), several possible explanations have been postulated, including limitations in the analysis of results from preclinical evidence. Therefore, to address this question, a systematic review and meta-analysis was performed to evaluate the effects of progesterone as a neuroprotective agent in preclinical animal models of TBI. A total of 48 studies were included for review: 29 evaluated brain edema, 21 evaluated lesion size, and 0 studies reported the survival rate. In the meta-analysis, it was found that progesterone reduced brain edema (effect size − 1.73 [− 2.02, − 1.44], p  
ISSN:0893-7648
1559-1182
DOI:10.1007/s12035-022-02970-9