Au-doped MOFs catalyzed electrochemiluminescence platform coupled with target-induced self-enrichment for detection of synthetic cannabinoid RCS-4

• Published in: Mikrochimica acta (1966) 2022-09, Vol.189 (9), p.313-313, Article 313
• Main Authors: Cao, Qianying, Jiang, Ding, Xu, Fangmin, Wen, Jing, Wang, Wenchang, Shiigi, Hiroshi, Chen, Zhidong
• Format: Article
• Language: English
• Subjects: Adsorption; Analytical Chemistry; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Comparative analysis; Composite materials; Electrochemiluminescence; Microengineering; Nanochemistry; Nanotechnology; Original Paper; Public health; Sensitivity; Sensors; Stability; Target detection
• ISSN: 0026-3672; 1436-5073
• DOI: 10.1007/s00604-022-05397-0

A ternary composite material with Au, Co-based organic frameworks (ZIF-67) and perylene derivatives (PTCD-cys) has been synthesized for identification of synthetic cannabinoids. Through contact with Au–S, Au-ZIF-67 increased electrochemiluminescence (ECL) sensitivity and stability and efficiently catalyzed the ECL of PTCD-cys. Compared with the ECL response of PTCD-cys monomer, the ECL signal value of the composite material was significantly increased, and the onset potential of Au-ZIF-67/PTCD-cys favorably shifted more than that of PTCD-cys/GCE. When the target cannabinoid molecule RCS-4 appeared, Au-ZIF-67 captured and immobilized it on the sensor surface by adsorption to achieve target-induced self-enrichment of RCS-4. Under optimal conditions, the ECL sensor was found to be linearly related to the logarithm of the RCS-4 concentration ranging from 3.1 × 10 −15 to 3.1 × 10 −9  mol/L with a detection limit (LOD) of 6.0 × 10 −16  mol/L (S/N = 3). The approach had the advantages of being simple to use, having a high sensitivity, a wide detection range, and good stability, making it a novel platform for RSC-4 detection in public health safety monitoring. Graphical abstract