Mannose binding lectin‐associated serine protease 2 (MASP2) gene polymorphism and susceptibility to human T‐lymphotropic virus type 1 (HTLV‐1) infection in blood donors from Mashhad, Iran

Mannose binding lectin‐associated serine protease 2 (MASP2) is the effector part of mannose binding lectin (MBL) that activates the complement system in an antibody‐independent manner. We aimed to investigate the role of genetic polymorphisms in the MASP2 gene and susceptibility to HTLV‐1 infection....

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Bibliographic Details
Published in:Microbiology and immunology 2022-10, Vol.66 (10), p.460-464
Main Authors: Aghamohammadi, Akram, Rafatpanah, Houshang, Maghsoodlu, Mahtab, Tohidi, Nastaran, Mollahosseini, Farzad, Shahabi, Majid
Format: Article
Language:English
Subjects:
Blood donors
Complement activation
Gene polymorphism
HTLV‐1
Infections
lectin pathway
Lectins
Mannose
Mannose-binding lectin
MASP-2 protein
MASP2
MASP2 gene
Polymerase chain reaction
Serine
Serine proteinase
Single-nucleotide polymorphism
SNP
Statistical analysis
Susceptibility
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Summary:Mannose binding lectin‐associated serine protease 2 (MASP2) is the effector part of mannose binding lectin (MBL) that activates the complement system in an antibody‐independent manner. We aimed to investigate the role of genetic polymorphisms in the MASP2 gene and susceptibility to HTLV‐1 infection. A total of 172 HTLV‐1 infected individuals and 170 healthy blood donors were analyzed in this case–control study. Nine single nucleotide polymorphisms (SNPs) encompassing different regions of the MASP2 gene were genotyped with a polymerase chain reaction‐sequence‐specific primer (PCR‐SSP) assay. The relation between the SNPs genotype and the susceptibility to HTLV‐1 infection was investigated with a χ2 test considering P 
ISSN:0385-5600
1348-0421
DOI:10.1111/1348-0421.13022