Predictive value of video alone in diagnosis of epileptic vs paroxysmal nonepileptic events in children

• Published in: Epilepsy & behavior 2022-09, Vol.134, p.108863-108863, Article 108863
• Main Authors: Burr, Tyler, Modiano, Yosefa, Raichur, Prachi, Barton, Christopher, Sah, Jeetendra, Farber, Darren, Brock, Dylan, Karia, Samir, Haneef, Zulfi, Karakas, Cemal
• Format: Article
• Language: English
• Subjects: Children; EMU; Epilepsy; Epileptic seizure; Nonepileptic event; Seizure prediction; Video
• ISSN: 1525-5050; 1525-5069
• DOI: 10.1016/j.yebeh.2022.108863

•A video alone can help accurately classify spells as PNEE vs ES in children.•Videos are 74.5% accurate in differentiating ES from PNEE in children.•Additional clinical data improved specificity of diagnostic ratings of the videos.•Facial expressions, generalized stiffening, eye blinking/deviation are more likely seen in ES.•Nonepileptic videos may more likely show bilateral myoclonic jerking in children. Previous studies examined the use of video-based diagnosis and the predictive value of videos for differentiation of epileptic seizures (ES) from paroxysmal nonepileptic events (PNEE) in the adult population. However, there are no such published studies strictly on the pediatric population. Using video-EEG diagnosis as a gold standard, we aimed to determine the diagnostic predictive value of videos of habitual events with or without additional clinical data in differentiating the PNEE from ES in children. Consecutive admissions to our epilepsy monitoring unit between June 2020 and December 2020 were analyzed for events of interest. Four child neurologists blinded to the patient’s diagnosis formulated a diagnostic impression based upon the review of the video alone and again after having access to basic clinical information, in addition to the video. Features of the video which helped to make a diagnosis were identified by the reviewers as a part of a survey. A total of 54 patients were included (ES n = 24, PNEE n = 30). Diagnostic accuracy was calculated for each reviewer and combined across all the ratings. Diagnostic accuracy by video alone was 74.5% (sensitivity 80.8%, specificity 66.7%). Providing reviewers with basic clinical information in addition to the videos significantly improved diagnostic accuracy compared to viewing the videos alone. Inter-rater reliability between four reviewers based on the video alone showed moderate agreement (κ = 0.51) and unchanged when additional clinical data were presented (κ = 0.51). The ES group was significantly more likely to demonstrate changes in facial expression, generalized stiffening, repetitive eye blinks, and eye deviation when compared with the PNEE group, which was more likely to display bilateral myoclonic jerking. Video review of habitual events by Child Neurologists may be helpful in reliably distinguishing ES from PNEE in children, even without included clinical information.