Predictors of Peak Expiratory Cough Flow in Individuals with Amyotrophic Lateral Sclerosis

Dystussia is prevalent in individuals with amyotrophic lateral sclerosis (ALS), leading to a diminished physiologic capacity to effectively defend the airway. We aimed to identify predictors of peak expiratory cough flow rate in individuals with ALS. One hundred and thirty-four individuals with a co...

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Bibliographic Details
Published in:Dysphagia 2023-04, Vol.38 (2), p.719-725
Main Authors: Tabor Gray, Lauren, McElheny, Kasey L., Vasilopoulos, Terrie, Wymer, James, Smith, Barbara K., Plowman, Emily K.
Format: Article
Language:English
Subjects:
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - complications
Amyotrophic Lateral Sclerosis - physiopathology
Analysis
Compression
Cough
Cough - etiology
Development and progression
Dysphagia
Exhalation
Gastroenterology
Hepatology
Humans
Imaging
Linear Models
Medical diagnosis
Medicine
Medicine & Public Health
Original Article
Otorhinolaryngology
Prediction models
Pressure
Radiology
Respiration
Respiratory function
Respiratory tract
Severity of Illness Index
Spirometry
Therapeutic targets
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Summary:Dystussia is prevalent in individuals with amyotrophic lateral sclerosis (ALS), leading to a diminished physiologic capacity to effectively defend the airway. We aimed to identify predictors of peak expiratory cough flow rate in individuals with ALS. One hundred and thirty-four individuals with a confirmed diagnosis of ALS (El-Escorial criteria revised) completed the ALS Functional Rating Scale-Revised (ALSFRS-R) and underwent pulmonary function and cough spirometry testing. Pearson’s correlation coefficients and hierarchical multiple regression modeling were conducted to determine predictors of voluntary cough peak expiratory flow rate ( p  
ISSN:0179-051X
1432-0460
DOI:10.1007/s00455-022-10503-8