Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments

Metal-organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments via the dissolution...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2022-09, Vol.58 (72), p.14-17
Main Authors: Gan, Lei, Velásquez-Hernández, Miriam de J, Emmerstorfer-Augustin, Anita, Wied, Peter, Wolinski, Heimo, Zilio, Simone Dal, Solomon, Marcello, Liang, Weibin, Doonan, Christian, Falcaro, Paolo
Format: Article
Language:English
Subjects:
Chemistry
Composite structures
Metal-organic frameworks
Multilayers
Protease
Protease inhibitors
Shells (structural forms)
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Summary:Metal-organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments via the dissolution of the shells and release of a protease inhibitor (antitrypsin). Living cells are coated with a multi-layered MOF biocomposite shell: the shell dissolution releases a biotherapeutic (antitrypsin) that provides artificial adaptability to protease-rich environments.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc03072a