Targeting endoplasmic reticulum stress using natural products in neurological disorders

The primary aim of this review is to summarize the literature on natural products that are effective in the treatment of various neurological disorders by targeting endoplasmic reticulum stress (ERS). Various electronic databases such as SCOPUS, PubMed, Web of Science, and Google Scholar were search...

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Published in:Neuroscience and biobehavioral reviews 2022-10, Vol.141, p.104818-104818, Article 104818
Main Authors: Jangra, Ashok, Verma, Mehak, Kumar, Deepak, Chandrika, Rachamalla, Mahesh, Dey, Abhijit, Dua, Kamal, Jha, Saurabh Kumar, Ojha, Shreesh, Alexiou, Athanasios, Kumar, Dinesh, Jha, Niraj Kumar
Format: Article
Language:English
Subjects:
Alzheimer’s disease
Endoplasmic reticulum stress
Natural products
Neurodegenerative diseases
Neurological disorders
Neuroprotection
Neuroprotective agents
Parkinson’s disease
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Summary:The primary aim of this review is to summarize the literature on natural products that are effective in the treatment of various neurological disorders by targeting endoplasmic reticulum stress (ERS). Various electronic databases such as SCOPUS, PubMed, Web of Science, and Google Scholar were searched for relevant publications. ERS has been implicated in the pathogenesis of numerous neurological disorders such as cerebral ischemia, Parkinson's disease, and Alzheimer's disease. Several natural products targeting ERS signalling pathways provide therapeutic options for neurological diseases, and in this review, the potential neuroprotective properties of these products are discussed. [Display omitted] •Endoplasmic reticulum stress (ESR) induced by buildup of un-/mis-folded proteins.•Reports claim that ERS is crucial in the pathogenesis of neurological diseases.•Modulation of ERS and ERS-mediated apoptosis may alleviate neurological diseases.•Review discusses role of natural products in targeting the ERS signalling pathway.
ISSN:0149-7634
1873-7528
DOI:10.1016/j.neubiorev.2022.104818