Dantrolene, a stabilizer of the ryanodine receptor, prevents collagen-induced arthritis

Dantrolene inhibits Ca2+ leakage from destabilized ryanodine receptors and therefore may serve as a therapeutic agent against endoplasmic reticulum stress-associated diseases. However, its effectiveness in treating autoimmune diseases remains unclear. Here, we investigated the effect of dantrolene o...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2022-10, Vol.624, p.141-145
Main Authors: Nawata, Takashi, Sakai, Hiroki, Honda, Takeshi, Otsuka, Marina, Fujita, Hina, Uchinoumi, Hitoshi, Kobayashi, Shigeki, Yamamoto, Takeshi, Asagiri, Masataka, Yano, Masafumi
Format: Article
Language:English
Subjects:
Collagen-induced arthritis
Dantrolene
Rheumatoid arthritis
Ryanodine receptor
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Summary:Dantrolene inhibits Ca2+ leakage from destabilized ryanodine receptors and therefore may serve as a therapeutic agent against endoplasmic reticulum stress-associated diseases. However, its effectiveness in treating autoimmune diseases remains unclear. Here, we investigated the effect of dantrolene on collagen-induced arthritis (CIA) in mice. Oral administration of dantrolene resulted in significantly lower arthritic scores in both male and female CIA mice than in the control mice. Micro-computed tomographic and histological analyses showed that dantrolene suppressed bone and chondral destruction. The serum levels of anti-type II collagen (CII) IgG were positively correlated with the arthritic scores (r = 0.704, p 
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2022.07.111