Phenolic Glycosides from the Leaves of Iodes cirrhosa Turcz. with Cytotoxic and Antimicrobial Effects

In the present study, 14 phenolic glycosides, including one new neolignan glycoside, iodescirrhoside A (1), three new flavonol glycosides, iodescirrhosides B–D (2–4), and 10 known metabolites were obtained from the methanol extract of Iodes cirrhosa leaves. Structural elucidation was performed by in...

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Bibliographic Details
Published in:Chemistry & biodiversity 2022-09, Vol.19 (9), p.e202200182-n/a
Main Authors: Thi Ngoc, Ninh, Hong Quang, Tran, Thi Hong Hanh, Tran, Xuan Cuong, Nguyen, The Cuong, Nguyen, Hoang Ha, Chu, Hoai Nam, Nguyen, Van Minh, Chau
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
antimicrobial activity
Antimicrobial agents
cytotoxic activity
Cytotoxicity
Flavonols
Glycosides
Icacinaceae
Iodes cirrhosa
Metabolites
NMR
Nuclear magnetic resonance
Phenolic compounds
phenolic glycoside
Phenols
Tumor cell lines
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Summary:In the present study, 14 phenolic glycosides, including one new neolignan glycoside, iodescirrhoside A (1), three new flavonol glycosides, iodescirrhosides B–D (2–4), and 10 known metabolites were obtained from the methanol extract of Iodes cirrhosa leaves. Structural elucidation was performed by interpretating the 1D‐ and 2D‐ NMR, HR‐ESI‐MS, and CD spectra in comparison with literature data. All compounds were noncytotoxic to LU‐1, HepG2, MCF‐7, SK‐Mel‐2, and LNCaP cancer cell lines. Compound 11 significantly inhibited the growth of E. faecalis. In contrast, weak inhibition was observed for 1–9 and 14 against E. faecalis, for 1, 6–8, and 11 against S. aureus, for 6 and 13 against B. cereus, and 2, 4, and 6–9 against C. albicans.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202200182