Iron quantitative analysis of motor combined with bulbar region in M1 cortex may improve diagnosis performance in ALS

• Published in: European radiology 2023-02, Vol.33 (2), p.1132-1142
• Main Authors: Bao, Yifang, Chen, Yan, Piao, Sirong, Hu, Bin, Yang, Liqin, Li, Haiqing, Geng, Daoying, Li, Yuxin
• Format: Article
• Language: English
• Subjects: Aged; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - diagnostic imaging; Biomarkers; Diagnosis; Diagnostic Radiology; Disease Progression; Humans; Imaging; Internal Medicine; Interventional Radiology; Iron; Magnetic Resonance Imaging - methods; Medical diagnosis; Medical imaging; Medicine; Medicine & Public Health; Motor Cortex - diagnostic imaging; Motor task performance; Neuro; Neuroimaging; Neuroradiology; Older people; Quantitative analysis; Radiology; Retrospective Studies; Ultrasound
• ISSN: 1432-1084; 0938-7994; 1432-1084
• DOI: 10.1007/s00330-022-09045-2

Objectives To explore whether the combined analysis of motor and bulbar region of M1 on susceptibility-weighted imaging (SWI) can be a valid biomarker for amyotrophic lateral sclerosis (ALS). Methods Thirty-two non-demented ALS patients and 35 age- and gender-matched healthy controls (HC) were retrospectively recruited. SWI and 3D-T1-MPRAGE images were obtained from all individuals using a 3.0-T MRI scan. The bilateral posterior band of M1 was manually delineated by three neuroradiologists on phase images and subdivided into the motor and bulbar regions. We compared the phase values in two groups and performed a stratification analysis (ALSFRS-R score, duration, disease progression rate, and onset). Receiver operating characteristic (ROC) curves were also constructed. Results ALS group showed significantly increased phase values in M1 and the two subregions than the HC group, on the all and elderly level ( p < 0.001, respectively). On all-age level comparison, negative correlations were found between phase values of M1 and clinical score and duration ( p < 0.05, respectively). Similar associations were found in the motor region ( p < 0.05, respectively). On both the total ( p < 0.01) and elderly ( p < 0.05) levels, there were positive relationships between disease progression rate and M1 phase values. In comparing ROC curves, the entire M1 showed the best diagnostic performance. Conclusions Combining motor and bulbar analyses as an integral M1 region on SWI can improve ALS diagnosis performance, especially in the elderly. The phase value could be a valuable biomarker for ALS evaluation. Key Points • Integrated analysis of the motor and bulbar as an entire M1 region on SWI can improve the diagnosis performance in ALS. • Quantitative analysis of iron deposition by SWI measurement helps the clinical evaluation, especially for the elderly patients. • Phase value, when combined with the disease progression rate, could be a valuable biomarker for ALS.