Echocardiographic assessment of cardiovascular function and clinical outcomes in liver transplant recipients

Background & Aims Cardiovascular disease contributes to a high rate of morbidity and mortality after liver transplantation (LT). However, the progression of cardiac function and cardiac remodeling in LT recipients remains poorly understood. This study sought to evaluate the progression of cardia...

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Bibliographic Details
Published in:Clinical transplantation 2022-11, Vol.36 (11), p.e14793-n/a
Main Authors: Lim, Wen Hui, Chew, Nicholas WS, Quek, Jingxuan, Ng, Cheng Han, Tan, Darren Jun Hao, Xiao, Jieling, Nah, Benjamin, Lee, Guan Huei, Huang, Daniel Q., Tan, Eunice Xiang Xuan, Muthiah, Mark D.
Format: Article
Language:English
Subjects:
Adult
diagnostic imaging
Echocardiography
Heart Failure
Humans
liver transplantation
Liver Transplantation - adverse effects
myocardial contraction
Retrospective Studies
Stroke Volume
Ventricular Function, Left
ventricular remodeling
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Summary:Background & Aims Cardiovascular disease contributes to a high rate of morbidity and mortality after liver transplantation (LT). However, the progression of cardiac function and cardiac remodeling in LT recipients remains poorly understood. This study sought to evaluate the progression of cardiac function and structure in LT recipients and identify independent predictors of prognosis using echocardiography. Methods From 2009 to 2019, 178 adult LT recipients at a tertiary academic transplant center were retrospectively studied. Transthoracic echocardiograms 1‐year pre‐ and post‐LT were assessed. Primary outcomes were progression of systolic and diastolic function. Secondary outcomes included left ventricular remodeling, all‐cause mortality, and heart failure readmission post‐LT. Subgroup analyzes were performed for etiology of native liver disease. A multivariable model was constructed to examine independent predictors of outcomes. Results Systolic function significantly worsened, with reduction in stroke volume (45–37 ml/m2, p 
ISSN:0902-0063
1399-0012
DOI:10.1111/ctr.14793