CircSHOC2 Knockdown Alleviates High Glucose-Induced Vascular Endothelial Cell Pyroptosis via Targeting miR-145/FOXO1 Axis In Vitro Condition

Emerging evidence indicates that pyroptosis participates in the pathogenic process of vascular endothelial cells in cardiovascular system complications of diabetes. The roles of circular RNAs (circRNAs) in high glucose (HG)-induced vascular endothelial cells are still unclear. Here, our research inv...

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Bibliographic Details
Published in:Molecular biotechnology 2023-03, Vol.65 (3), p.384-393
Main Authors: Meng, Xuying, Li, Zhenjin, Li, Yang
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - genetics
Biochemistry
Biological Techniques
Biotechnology
Cardiovascular system
Cell Biology
Cells
Chemistry
Chemistry and Materials Science
Diabetes
Diabetes Complications - pathology
Diabetes mellitus
Endothelial cells
Forkhead Box Protein O1 - genetics
FOXO1 protein
Glucose
Glucose - pharmacology
Human Genetics
Human Umbilical Vein Endothelial Cells
Humans
Hyperglycemia
Lung cancer
MicroRNAs
MicroRNAs - genetics
miRNA
Original Paper
Plasmids
Protein Science
Pyroptosis
Pyroptosis - genetics
RNA, Circular - genetics
Software
Umbilical vein
Veins & arteries
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Summary:Emerging evidence indicates that pyroptosis participates in the pathogenic process of vascular endothelial cells in cardiovascular system complications of diabetes. The roles of circular RNAs (circRNAs) in high glucose (HG)-induced vascular endothelial cells are still unclear. Here, our research investigated the function and mechanism of circRNA circSHOC2 in pyroptosis of vascular endothelial cells. Results indicated that circSHOC2 was up-regulated in HG-induced human umbilical vein endothelial cells (HUVECs). Functionally, cellular assays indicated that circSHOC2 silencing repressed HG-induced HUVECs pyroptosis. Moreover, circSHOC2 targeted miR-145 through miRNA sponge, and FOXO1 functioned as downstream target of miR-145. In conclusion, these findings suggested the potential roles of circSHOC2 on HG-induced vascular endothelial cells in vitro condition, providing new insights for cardiovascular system complications of diabetes.
ISSN:1073-6085
1559-0305
DOI:10.1007/s12033-022-00544-7