Impact of Seasonal Coronavirus Antibodies on Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Responses in Solid Organ Transplant Recipients

Abstract Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination are reduced in solid organ transplant recipients (SOTRs). We report that increased levels of preexisting antibodies to seasonal coronaviruses are associated with decreased antibody response to SAR...

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Bibliographic Details
Published in:Clinical infectious diseases 2023-02, Vol.76 (3), p.e495-e498
Main Authors: Karaba, Andrew H, Zhou, Weiqiang, Li, Shuai, Aytenfisu, Tihitina Y, Johnston, Trevor S, Akinde, Olivia, Eby, Yolanda, Abedon, Aura T, Alejo, Jennifer L, Qin, Caroline X, Thompson, Elizabeth A, Garonzik-Wang, Jacqueline M, Blankson, Joel N, Cox, Andrea L, Bailey, Justin R, Klein, Sabra L, Pekosz, Andrew, Segev, Dorry L, Tobian, Aaron A R, Werbel, William A
Format: Article
Language:English
Subjects:
Antibodies, Viral
COVID-19 - prevention & control
COVID-19 Vaccines - adverse effects
Humans
Organ Transplantation - adverse effects
SARS-CoV-2
Seasons
Transplant Recipients
Vaccination
Vaccines
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Summary:Abstract Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination are reduced in solid organ transplant recipients (SOTRs). We report that increased levels of preexisting antibodies to seasonal coronaviruses are associated with decreased antibody response to SARS-CoV-2 vaccination in SOTRs, supporting that antigenic imprinting modulates vaccine responses in SOTRs.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciac652