Can Radiotherapy After Breast-Conserving Surgery be Omitted in Elderly Patients with Early-Stage, Hormone-Receptor Negative Breast Cancer? A Population-Based Study and Proposed Nomogram

• Published in: Advances in therapy 2022-10, Vol.39 (10), p.4707-4722
• Main Authors: Xu, Li, Zhou, Chen, Qiu, Juanjuan, Lv, Qing, Du, Zhenggui
• Format: Article
• Language: English
• Subjects: Aged; Breast Neoplasms - radiotherapy; Breast Neoplasms - surgery; Cardiology; Endocrinology; Female; Hormones; Humans; Internal Medicine; Mastectomy, Segmental - methods; Medicine; Medicine & Public Health; Neoplasm Staging; Nomograms; Oncology; Original Research; Pharmacology/Toxicology; Prospective Studies; Rheumatology; SEER Program; Triple Negative Breast Neoplasms
• ISSN: 0741-238X; 1865-8652
• DOI: 10.1007/s12325-022-02279-y

Introduction We aimed to evaluate whether radiotherapy (RT) after breast-conserving surgery (BCS) can be omitted in elderly patients with early-stage, hormone receptor-negative breast cancer. Methods Patients aged 65 years and older with T1–2N0–1, hormone receptor-negative breast cancer in 2010–2015 were extracted from the Surveillance, Epidemiology, and End Results program. Propensity score matching was used to balance the baseline of different groups. Survival analysis was performed using Kaplan–Meier plot and log-rank test. Independent risk factors were identified by multivariate Cox analysis. A nomogram predicting breast cancer-specific survival (BCSS) and a risk stratification model were constructed and validated. Results A total of 4465 patients were included and 27.7% (1237/4465) patients did not receive postoperative RT. RT was significantly associated with improved overall survival (OS) (HR = 0.552 P