Bioactive Secondary Metabolites Isolated from the Antarctic Lichen Himantormia lugubris

Two new depsidones, himantormiones A and B (1 and 2) were isolated and identified from the Antarctic lichen, Himantormia lugubris (Parmeliaceae), with seven known compounds (3–9). The structures of two new compounds (1 and 2) were determined by means of spectroscopic analyses, including 1D and 2D NM...

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Bibliographic Details
Published in:Chemistry & biodiversity 2022-10, Vol.19 (10), p.e202200374-n/a
Main Authors: Hyung Koo, Man, Shin, Min‐Ji, Ju Kim, Min, Lee, Seulah, Eun So, Jae, Hee Kim, Ji, Hyuck Lee, Jun, Suh, Sung‐Suk, Joung Youn, Ui
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
antimicrobial
Antimicrobial agents
Colon
Colon cancer
Cytotoxicity
depsidone
Himantormia
Himantormia lugubris
lichen
Lichens
Metabolites
NMR
Nuclear magnetic resonance
Polar environments
Secondary metabolites
Two dimensional analysis
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Summary:Two new depsidones, himantormiones A and B (1 and 2) were isolated and identified from the Antarctic lichen, Himantormia lugubris (Parmeliaceae), with seven known compounds (3–9). The structures of two new compounds (1 and 2) were determined by means of spectroscopic analyses, including 1D and 2D NMR and HR‐MS. The isolated compounds were tested for antimicrobial and cytotoxic activities, where himantormione B (2) exhibited inhibitory effect against Staphylococcus aureus with the IC50 value of 7.01±0.85 mM. Compound 2 also exhibited strong cytotoxic activity against HCT116 cells (colon cancer) with the EC50 value of 1.11±0.85 μM, where that of the positive control, 5‐fluouracil, was 9.4±1.90 μM.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202200374