Bioactive Secondary Metabolites Isolated from the Antarctic Lichen Himantormia lugubris

Two new depsidones, himantormiones A and B (1 and 2) were isolated and identified from the Antarctic lichen, Himantormia lugubris (Parmeliaceae), with seven known compounds (3–9). The structures of two new compounds (1 and 2) were determined by means of spectroscopic analyses, including 1D and 2D NM...

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Published in:Chemistry & biodiversity 2022-10, Vol.19 (10), p.e202200374-n/a
Main Authors: Hyung Koo, Man, Shin, Min‐Ji, Ju Kim, Min, Lee, Seulah, Eun So, Jae, Hee Kim, Ji, Hyuck Lee, Jun, Suh, Sung‐Suk, Joung Youn, Ui
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
antimicrobial
Antimicrobial agents
Colon
Colon cancer
Cytotoxicity
depsidone
Himantormia
Himantormia lugubris
lichen
Lichens
Metabolites
NMR
Nuclear magnetic resonance
Polar environments
Secondary metabolites
Two dimensional analysis
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cited_by cdi_FETCH-LOGICAL-c2804-dcb89109825d2ab2f2789c680fe38c40aa15ea732ac415a6cc25666f0c115d923
cites cdi_FETCH-LOGICAL-c2804-dcb89109825d2ab2f2789c680fe38c40aa15ea732ac415a6cc25666f0c115d923
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container_issue 10
container_start_page e202200374
container_title Chemistry & biodiversity
container_volume 19
creator Hyung Koo, Man
Shin, Min‐Ji
Ju Kim, Min
Lee, Seulah
Eun So, Jae
Hee Kim, Ji
Hyuck Lee, Jun
Suh, Sung‐Suk
Joung Youn, Ui
description Two new depsidones, himantormiones A and B (1 and 2) were isolated and identified from the Antarctic lichen, Himantormia lugubris (Parmeliaceae), with seven known compounds (3–9). The structures of two new compounds (1 and 2) were determined by means of spectroscopic analyses, including 1D and 2D NMR and HR‐MS. The isolated compounds were tested for antimicrobial and cytotoxic activities, where himantormione B (2) exhibited inhibitory effect against Staphylococcus aureus with the IC50 value of 7.01±0.85 mM. Compound 2 also exhibited strong cytotoxic activity against HCT116 cells (colon cancer) with the EC50 value of 1.11±0.85 μM, where that of the positive control, 5‐fluouracil, was 9.4±1.90 μM.
doi_str_mv 10.1002/cbdv.202200374
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source Wiley-Blackwell Read & Publish Collection
subjects Antiinfectives and antibacterials
antimicrobial
Antimicrobial agents
Colon
Colon cancer
Cytotoxicity
depsidone
Himantormia
Himantormia lugubris
lichen
Lichens
Metabolites
NMR
Nuclear magnetic resonance
Polar environments
Secondary metabolites
Two dimensional analysis
title Bioactive Secondary Metabolites Isolated from the Antarctic Lichen Himantormia lugubris
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