Manganese oxide increases bleaching efficacy and reduces the cytotoxicity of a 10% hydrogen peroxide bleaching gel

• Published in: Clinical oral investigations 2022-12, Vol.26 (12), p.7277-7286
• Main Authors: de Oliveira Ribeiro, Rafael Antonio, Zuta, Uxua Ortecho, Soares, Igor Paulino Mendes, Anselmi, Caroline, Soares, Diana Gabriela, Briso, André Luiz Fraga, Hebling, Josimeri, de Souza Costa, Carlos Alberto
• Format: Article
• Language: English
• Subjects: Bleaching; Cytotoxicity; Degradation; Dental enamel; Dental pulp; Dentistry; Hydrogen peroxide; Manganese; Manganese oxides; Medicine; Original Article
• ISSN: 1436-3771; 1432-6981; 1436-3771
• DOI: 10.1007/s00784-022-04688-3

Objective The study aims to assess the effects of a 10% H 2 O 2 bleaching gel with different MnO 2 concentrations on the bleaching efficacy (BE), degradation kinetics (DK) of H 2 O 2 , and trans-amelodentinal cytotoxicity (TC). Materials and methods Standardized bovine enamel/dentin disks ( n  = 96) were placed in artificial pulp chambers, and the bleaching gels were applied for 45 min. Thus, the following groups were established: (G1) no treatment (negative control/NC); (G2) 35% H 2 O 2 (positive control/PC); (G3) 10% H 2 O 2 ; (G4) 10% H 2 O 2  + 2 mg/mL MnO 2 ; (G5) 10% H 2 O 2  + 6 mg/mL MnO 2 ; and (G6) 10% H 2 O 2  + 10 mg/mL MnO 2 . After analyzing bleaching efficacy (Δ E 00 and ΔWI), the degradation kinetics of H 2 O 2 and trans-amelodentinal cytotoxicity were determined ( n  = 8, ANOVA/Tukey; p   0.9999). A significant reduction in the diffusion of H 2 O 2 occurred in G3, G4, G5, and G6 compared to G2 ( p