Two smoking-related lesions in the same pulmonary lobe of squamous cell carcinoma and pulmonary Langerhans cell histiocytosis: A case report

BACKGROUNDPulmonary Langerhans cell histiocytosis (PLCH) is a rare cystic lung disease usually affecting young adults. It is predicted that PLCH is a lung tumor precursor associated with dysfunction of the myeloid dendritic cells in the lung. CASE SUMMARYA 70-year-old male patient presented with chr...

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Bibliographic Details
Published in:World journal of clinical cases 2022, Vol.10 (19), p.6722-6727
Main Authors: Gencer, Aysegul, Ozcibik, Gizem, Karakas, Fatma Gulsum, Sarbay, Ismail, Batur, Sebnem, Borekci, Sermin, Turna, Akif
Format: Report
Language:English
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Summary:BACKGROUNDPulmonary Langerhans cell histiocytosis (PLCH) is a rare cystic lung disease usually affecting young adults. It is predicted that PLCH is a lung tumor precursor associated with dysfunction of the myeloid dendritic cells in the lung. CASE SUMMARYA 70-year-old male patient presented with chronic cough and sputum. He had symptoms for 5 years and described shortness of breath on exertion for the previous 3 years. He had a 60 packs/year smoking history. Computerized tomography of the thorax revealed an 11-mm nodule in the right lung lower lobe superior segment and a 7-mm nodule in the right lung lower lobe poster basal segment. Those two nodules were resected by means of right thoracoscopic surgery. Pathological evaluation revealed a squamous cell carcinoma and PLCH. CONCLUSIONCoexistent squamous cell carcinoma and PLCH suggest possible association between PLCH and lung cancer.
ISSN:2307-8960
2307-8960
DOI:10.12998/wjcc.v10.i19.6722