Microfluidic systems in clinical diagnosis

The use of microfluidic devices is highly attractive in the field of biomedical and clinical assessments, as their portability and fast response time have become crucial in providing opportune therapeutic treatments to patients. The applications of microfluidics in clinical diagnosis and point‐of‐ca...

Full description

Saved in:
Bibliographic Details
Published in:Electrophoresis 2023-01, Vol.44 (1-2), p.217-245
Main Authors: Lapizco‐Encinas, Blanca H., Zhang, Yan Victoria
Format: Article
Language:English
Subjects:
Analytical chemistry
Assessments
biomedical analysis
Body fluids
clinical diagnosis
Cost analysis
Diagnosis
Humans
Lab-On-A-Chip Devices
laboratory medicine
Metabolites
Microfluidic Analytical Techniques
Microfluidics
miniaturization
Point-of-Care Systems
Proteins
Proteomics
Response time
Sugar
Wearable Electronic Devices
Wearable technology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The use of microfluidic devices is highly attractive in the field of biomedical and clinical assessments, as their portability and fast response time have become crucial in providing opportune therapeutic treatments to patients. The applications of microfluidics in clinical diagnosis and point‐of‐care devices are continuously growing. The present review article discusses three main fields where miniaturized devices are successfully employed in clinical applications. The quantification of ions, sugars, and small metabolites is examined considering the analysis of bodily fluids samples and the quantification of this type of analytes employing real‐time wearable devices. The discussion covers the level of maturity that the devices have reached as well as cost‐effectiveness. The analysis of proteins with clinical relevance is presented and organized by the function of the proteins. The last section covers devices that can perform single‐cell metabolomic and proteomic assessments. Each section discusses several strategically selected recent reports on microfluidic devices successfully employed for clinical assessments, to provide the reader with a wide overview of the plethora of novel systems and microdevices developed in the last 5 years. In each section, the novel aspects and main contributions of each reviewed report are highlighted. Finally, the conclusions and future outlook section present a summary and speculate on the future direction of the field of miniaturized devices for clinical applications.
ISSN:0173-0835
1522-2683
DOI:10.1002/elps.202200150