T cell immunity to COVID-19 vaccines

T cell immunity may be critical for long-term protection by COVID-19 vaccines The development of multiple COVID-19 vaccines in record time is a major biomedical achievement, but mechanistic immune correlates of vaccine protection remain to be determined. Most studies on COVID-19 vaccines have focuse...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2022-08, Vol.377 (6608), p.821-822
Main Authors: Wherry, E. John, Barouch, Dan H.
Format: Article
Language:English
Subjects:
Antibodies
Cell-mediated immunity
COVID-19
COVID-19 vaccines
Immunity
Infectious diseases
Lymphocytes
Lymphocytes T
Vaccines
Viral diseases
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Summary:T cell immunity may be critical for long-term protection by COVID-19 vaccines The development of multiple COVID-19 vaccines in record time is a major biomedical achievement, but mechanistic immune correlates of vaccine protection remain to be determined. Most studies on COVID-19 vaccines have focused on neutralizing antibody (NAb) responses, with little emphasis on cellular immunity. However, accumulating data suggest that T cell responses play an important role in vaccine protection against severe COVID-19 disease, particularly against viral variants that partially escape from recognition by NAbs. These insights have implications for using current COVID-19 vaccines and for developing next-generation vaccines against COVID-19 and other infectious diseases.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.add2897