Receptor-mediated mitophagy: An emerging therapeutic target in acute kidney injury

•Mitophagy, the selective removal of damaged mitochondria plays a key role in AKI pathogenesis.•Mitophagy can be mediated either by PINK1/Parkin or by receptors such as BNIP3, BNIP3L, AMBRA1, FUNDC1, SMURF1, etc.•Pharmacological modulation of the activity of mitophagy receptors has shown renoprotect...

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Bibliographic Details
Published in:Mitochondrion 2022-09, Vol.66, p.82-91
Main Authors: Dagar, Neha, Kale, Ajinath, Steiger, Stefanie, Anders, Hans-Joachim, Gaikwad, Anil Bhanudas
Format: Article
Language:English
Subjects:
Acute kidney injury
Mitochondria
Mitochondrial fusion/fission
Mitophagy
Mitophagy inducers
Receptor-mediated mitophagy
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Summary:•Mitophagy, the selective removal of damaged mitochondria plays a key role in AKI pathogenesis.•Mitophagy can be mediated either by PINK1/Parkin or by receptors such as BNIP3, BNIP3L, AMBRA1, FUNDC1, SMURF1, etc.•Pharmacological modulation of the activity of mitophagy receptors has shown renoprotection in AKI.•Receptor-mediated mitophagy induction can be explored further as a potential therapeutic target for AKI management. Acute kidney injury (AKI) is a global health concern associated with high morbidity and mortality. AKI etiology is linked to mitochondrial dysfunction along with oxidative stress and inflammation. The defective mitochondria are removed via mitophagy for maintaining cellular integrity. The main regulatory mechanisms of mitophagy in response to different stressors are Phosphatase and tensin homolog-induced kinase 1 (PINK1)/Parkin and receptor-mediated. Receptors like B-cell lymphoma 2/adenovirus E1B-interacting protein (BNIP3), BNIP3L, prohibitin2, tacrolimus (FK506)-binding protein8 (FKBP8), autophagy-beclin1-regulator1 (AMBRA1) and SMAD-ubiquitination regulatory factor1 (SMURF1), etc. participate in receptor-mediated mitophagy. In recent studies, receptor-mediated mitophagy showed protective effects in AKI. This review summarizes the evidence related to mitophagy in AKI and outlines the significance of receptor-mediated mitophagy modulation as a possible therapeutic approach in AKI.
ISSN:1567-7249
1872-8278
DOI:10.1016/j.mito.2022.08.004