Squamous cell carcinoma arising in an epidermal inclusion cyst

Squamous cell carcinoma (SCC) arising from an epidermal inclusion cyst (EIC) is uncommon. We present a case of a 70-year-old man with a scalp nodule with persistent discharge that was resected based on the clinical impression of an EIC. Histopathologic exam showed an infundibular EIC with an epiderm...

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Bibliographic Details
Published in:Proceedings - Baylor University. Medical Center 2022, Vol.35 (5), p.688-690
Main Authors: Alkul, Suzanne, Nguyen, Christopher N., Ramani, Nisha S., Alkul, Mahmud, Orengo, Ida, Shimizu, Ikue, Krishnan, Bhuvaneswari
Format: Article
Language:English
Subjects:
Cancer
Case Studies
Cysts
Diagnostic errors
epidermal cyst
Histopathology
neoplastic cell transformation
Review
Squamous cell carcinoma
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Summary:Squamous cell carcinoma (SCC) arising from an epidermal inclusion cyst (EIC) is uncommon. We present a case of a 70-year-old man with a scalp nodule with persistent discharge that was resected based on the clinical impression of an EIC. Histopathologic exam showed an infundibular EIC with an epidermal type of squamous epithelium; however, some of the cyst lining and lumen was replaced by squamous proliferation with malignant features. There are 56 cases of SCC arising in EICs reported in the English literature. Though suspected EICs are commonly benign, a thorough pathologic evaluation is required to rule out malignancy.
ISSN:0899-8280
1525-3252
DOI:10.1080/08998280.2022.2077600