Serum non‐coding RNAs for diagnosis and stage of liver fibrosis

Background All chronic liver diseases could lead to liver fibrosis. Accurate diagnosis and stage of fibrosis were important for the medical determination, management, and therapy. Liver biopsy was considered to be the gold criteria of fibrosis diagnosis. However, liver biopsy was an invasive method...

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Bibliographic Details
Published in:Journal of clinical laboratory analysis 2022-10, Vol.36 (10), p.e24658-n/a
Main Authors: Liu, Chao, Hou, Xueyun, Mo, Kaixin, Li, Nannan, An, Cheng, Liu, Guijian, Pan, Zongdai
Format: Article
Language:English
Subjects:
Biopsy
circRNA
Circular RNA
Diagnosis
Fibrosis
Hepatitis C
Liver
Liver diseases
liver fibrosis
lncRNA
Metabolism
microRNA
MicroRNAs
miRNA
Non-coding RNA
stage
Ultrasonic imaging
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Summary:Background All chronic liver diseases could lead to liver fibrosis. Accurate diagnosis and stage of fibrosis were important for the medical determination, management, and therapy. Liver biopsy was considered to be the gold criteria of fibrosis diagnosis. However, liver biopsy was an invasive method with some drawbacks. Non‐invasive tests for liver fibrosis included radiologic method and serum‐based test. Radiologic examination was influenced by obesity, cost, and availability. Serum‐based test was widely used in the screening and diagnostic of liver fibrosis. However, the accuracy was still needed to be improved. Methods Recent studies showed serum non‐coding RNAs: microRNA, long non‐coding RNA(lncRNA), and circular RNA(circRNA), which have the potentiality to be non‐invasive markers for liver fibrosis. The recent progress was summarized in this review. Results These studies showed serum non‐coding RNAs exerted a good diagnostic performance for liver fibrosis. A panel that included several non‐coding RNAs could increase the accuracy of single marker. Conclusions Serum microRNAs, lncRNAs, and circRNAs could be potential non‐invasive markers for diagnosis and stage of liver fibrosis. More high‐quality clinical study is needed for further research. MicroRNAs, lncRNAs, circRNAs and exosomes which were released from liver enter into circulating vessels. The blood which contain these molecules are drawed from patients. Then the blood specimen are tested for diagnose of early fibrosis or stage fibrosis in patients with liver diseases.
ISSN:0887-8013
1098-2825
DOI:10.1002/jcla.24658