Reduced IGFBP-2 related immunoreactivity in human serum correlates with arterial stiffness in a healthy Chinese population

• Published in: Microvascular research 2022-11, Vol.144, p.104423-104423, Article 104423
• Main Authors: Jin, Bo, Bai, Xiaojuan, Yu, Kai, Han, Lulu, Wang, Nan, Han, Wen
• Format: Article
• Language: English
• Subjects: A healthy population; Arterial stiffness; Insulin-like growth factor binding protein 2; Pulse wave velocity
• ISSN: 0026-2862; 1095-9319
• DOI: 10.1016/j.mvr.2022.104423

Circulating insulin-like growth factor binding protein 2 (IGFBP-2) is associated with metabolic changes in both physiological and pathological conditions. The aim of this study was to investigate the correlation between IGFBP-2 related immunoreactivity in serum and arterial stiffness in a healthy Chinese population. In this cross-sectional study, 360 healthy participants aged 37–87 years were recruited from 1500 and were divided into three groups according to serum IGFBP-2 related immunoreactivity (Tertile I, 25.437 ng/ml–120.870 ng/ml; Tertile II, 120.871 ng/ml–161.914 ng/ml; Tertile III, 161.915 ng/ml–321.636 ng/ml). Arterial stiffness was evaluated by measuring the brachial-ankle pulse wave velocity (baPWV), ankle-brachial index (ABI), and carotid intima-media thickness (cIMT). The association between IGFBP-2 related immunoreactivity and arterial stiffness was estimated by multiple stepwise regression. Compared with the other two groups population, the individuals in Tertile I had significantly older age (62.66 ± 13.30 years, P