Bauhinia forficata link extract attenuates insulin resistance by preserving glucose uptake in gastrocnemius muscle

• Published in: Natural product research 2023-06, Vol.37 (12), p.2031-2036
• Main Authors: Gasparini, Patricia, Garofolo, Ingrid Candido, Telles, Monica Marques, Oyama, Lila Missae, Veneza, Viviane de Mello, Moura Veiga, Thiago André, Flor Silveira, Vera Lucia, Caperuto, Luciana Chagas
• Format: Article
• Language: English
• Subjects: AKT protein; Animals; Attenuation; Bauhinia; Beta cells; Bioactive compounds; Blood Glucose - metabolism; Body weight; Body weight gain; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - drug therapy; Energy intake; Gastrocnemius muscle; Glucose; Glucose tolerance; High fat diet; Hypoglycemic Agents; In vivo methods and tests; Insulin; Insulin Resistance; Insulin secretion; Intolerance; Metabolites; Mice; Muscle, Skeletal - metabolism; Muscles; Preservation; Proto-Oncogene Proteins c-akt; Streptozocin; Weight reduction
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2022.2113875

Bioactive metabolites from Link (Bf extract) hold therapeutic potential for type 2 diabetes mellitus (T2DM) but the mechanism remains poorly understood. This study aimed to test the extract from Bf leaves obtained by decoction on the prevention of T2DM . The Bf extract was tested on a streptozotocin-induced T2DM mouse model fed on a high-fat diet. The insulin resistance was attenuated in T2DM animals supplemented with Bf extract, which indicates glucose intolerance reduction and p-AKT/AKT ratio preservation in the muscle. These observations suggested that Bf extract enhanced glucose uptake. Nevertheless, there was no preservation in β-cell insulin secretion in Bf extract-treated T2DM mice. Interestingly, the Bf extract reduced body weight gain without affecting total energy intake. Hence, Bf extract has a hypoglycemic effect which could attenuate the development of insulin resistance.