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Bauhinia forficata link extract attenuates insulin resistance by preserving glucose uptake in gastrocnemius muscle
Bioactive metabolites from Link (Bf extract) hold therapeutic potential for type 2 diabetes mellitus (T2DM) but the mechanism remains poorly understood. This study aimed to test the extract from Bf leaves obtained by decoction on the prevention of T2DM . The Bf extract was tested on a streptozotocin...
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| Published in: | Natural product research 2023-06, Vol.37 (12), p.2031-2036 |
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| Main Authors: | , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c384t-d11f3693b4fdaec4d5f5b063adb316e8970ac09ab84bd531b0e6b68f8e00f9ad3 |
| container_end_page | 2036 |
| container_issue | 12 |
| container_start_page | 2031 |
| container_title | Natural product research |
| container_volume | 37 |
| creator | Gasparini, Patricia Garofolo, Ingrid Candido Telles, Monica Marques Oyama, Lila Missae Veneza, Viviane de Mello Moura Veiga, Thiago André Flor Silveira, Vera Lucia Caperuto, Luciana Chagas |
| description | Bioactive metabolites from
Link (Bf extract) hold therapeutic potential for type 2 diabetes mellitus (T2DM) but the mechanism remains poorly understood. This study aimed to test the extract from Bf leaves obtained by decoction on the prevention of T2DM
. The Bf extract was tested on a streptozotocin-induced T2DM mouse model fed on a high-fat diet. The insulin resistance was attenuated in T2DM animals supplemented with Bf extract, which indicates glucose intolerance reduction and p-AKT/AKT ratio preservation in the
muscle. These observations suggested that Bf extract enhanced glucose uptake. Nevertheless, there was no preservation in β-cell insulin secretion in Bf extract-treated T2DM mice. Interestingly, the Bf extract reduced body weight gain without affecting total energy intake. Hence, Bf extract has a hypoglycemic effect which could attenuate the development of insulin resistance. |
| doi_str_mv | 10.1080/14786419.2022.2113875 |
| format | article |
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Link (Bf extract) hold therapeutic potential for type 2 diabetes mellitus (T2DM) but the mechanism remains poorly understood. This study aimed to test the extract from Bf leaves obtained by decoction on the prevention of T2DM
. The Bf extract was tested on a streptozotocin-induced T2DM mouse model fed on a high-fat diet. The insulin resistance was attenuated in T2DM animals supplemented with Bf extract, which indicates glucose intolerance reduction and p-AKT/AKT ratio preservation in the
muscle. These observations suggested that Bf extract enhanced glucose uptake. Nevertheless, there was no preservation in β-cell insulin secretion in Bf extract-treated T2DM mice. Interestingly, the Bf extract reduced body weight gain without affecting total energy intake. Hence, Bf extract has a hypoglycemic effect which could attenuate the development of insulin resistance.</description><identifier>ISSN: 1478-6419</identifier><identifier>EISSN: 1478-6427</identifier><identifier>DOI: 10.1080/14786419.2022.2113875</identifier><identifier>PMID: 35997243</identifier><language>eng</language><publisher>England: Taylor & Francis Ltd</publisher><subject>AKT protein ; Animals ; Attenuation ; Bauhinia ; Beta cells ; Bioactive compounds ; Blood Glucose - metabolism ; Body weight ; Body weight gain ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - drug therapy ; Energy intake ; Gastrocnemius muscle ; Glucose ; Glucose tolerance ; High fat diet ; Hypoglycemic Agents ; In vivo methods and tests ; Insulin ; Insulin Resistance ; Insulin secretion ; Intolerance ; Metabolites ; Mice ; Muscle, Skeletal - metabolism ; Muscles ; Preservation ; Proto-Oncogene Proteins c-akt ; Streptozocin ; Weight reduction</subject><ispartof>Natural product research, 2023-06, Vol.37 (12), p.2031-2036</ispartof><rights>2022 Informa UK Limited, trading as Taylor & Francis Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-d11f3693b4fdaec4d5f5b063adb316e8970ac09ab84bd531b0e6b68f8e00f9ad3</citedby><cites>FETCH-LOGICAL-c384t-d11f3693b4fdaec4d5f5b063adb316e8970ac09ab84bd531b0e6b68f8e00f9ad3</cites><orcidid>0000-0002-6008-4010 ; 0000-0002-1377-158X ; 0000-0002-7078-6526 ; 0000-0002-7576-5409 ; 0000-0003-4342-6688</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35997243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gasparini, Patricia</creatorcontrib><creatorcontrib>Garofolo, Ingrid Candido</creatorcontrib><creatorcontrib>Telles, Monica Marques</creatorcontrib><creatorcontrib>Oyama, Lila Missae</creatorcontrib><creatorcontrib>Veneza, Viviane de Mello</creatorcontrib><creatorcontrib>Moura Veiga, Thiago André</creatorcontrib><creatorcontrib>Flor Silveira, Vera Lucia</creatorcontrib><creatorcontrib>Caperuto, Luciana Chagas</creatorcontrib><title>Bauhinia forficata link extract attenuates insulin resistance by preserving glucose uptake in gastrocnemius muscle</title><title>Natural product research</title><addtitle>Nat Prod Res</addtitle><description>Bioactive metabolites from
Link (Bf extract) hold therapeutic potential for type 2 diabetes mellitus (T2DM) but the mechanism remains poorly understood. This study aimed to test the extract from Bf leaves obtained by decoction on the prevention of T2DM
. The Bf extract was tested on a streptozotocin-induced T2DM mouse model fed on a high-fat diet. The insulin resistance was attenuated in T2DM animals supplemented with Bf extract, which indicates glucose intolerance reduction and p-AKT/AKT ratio preservation in the
muscle. These observations suggested that Bf extract enhanced glucose uptake. Nevertheless, there was no preservation in β-cell insulin secretion in Bf extract-treated T2DM mice. Interestingly, the Bf extract reduced body weight gain without affecting total energy intake. Hence, Bf extract has a hypoglycemic effect which could attenuate the development of insulin resistance.</description><subject>AKT protein</subject><subject>Animals</subject><subject>Attenuation</subject><subject>Bauhinia</subject><subject>Beta cells</subject><subject>Bioactive compounds</subject><subject>Blood Glucose - metabolism</subject><subject>Body weight</subject><subject>Body weight gain</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Energy intake</subject><subject>Gastrocnemius muscle</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>High fat diet</subject><subject>Hypoglycemic Agents</subject><subject>In vivo methods and tests</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Insulin secretion</subject><subject>Intolerance</subject><subject>Metabolites</subject><subject>Mice</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscles</subject><subject>Preservation</subject><subject>Proto-Oncogene Proteins c-akt</subject><subject>Streptozocin</subject><subject>Weight reduction</subject><issn>1478-6419</issn><issn>1478-6427</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkU1v1DAQhiMEoqXwE0CWuPSyW3_HOUJFKVKlXuBsjZ3x4jZxFn9U9N-TVbc9cPLY88yrkZ-u-8jollFDL5jsjZZs2HLK-ZYzJkyvXnWnh_eNlrx__VKz4aR7V8odpZwppd52J0INQ8-lOO3yV2i_Y4pAwpJD9FCBTDHdE_xbM_hKoFZMDSoWElNpa49kLLFUSB6JeyT79Yr5IaYd2U3NLwVJ21e4x5UnOyg1Lz7hHFshcyt-wvfdmwBTwQ_H86z7dfXt5-X15ub2-4_LLzcbL4ysm5GxIPQgnAwjoJejCspRLWB0gmk0Q0_B0wGckW5UgjmK2mkTDFIaBhjFWXf-lLvPy5-Gpdo5Fo_TBAmXVizvqeoVXb9qRT__h94tLad1O8sNM0oKpfVKqSfK56WUjMHuc5whP1pG7UGKfZZiD1LsUco69-mY3tyM48vUswXxD6AlijM</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Gasparini, Patricia</creator><creator>Garofolo, Ingrid Candido</creator><creator>Telles, Monica Marques</creator><creator>Oyama, Lila Missae</creator><creator>Veneza, Viviane de Mello</creator><creator>Moura Veiga, Thiago André</creator><creator>Flor Silveira, Vera Lucia</creator><creator>Caperuto, Luciana Chagas</creator><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6008-4010</orcidid><orcidid>https://orcid.org/0000-0002-1377-158X</orcidid><orcidid>https://orcid.org/0000-0002-7078-6526</orcidid><orcidid>https://orcid.org/0000-0002-7576-5409</orcidid><orcidid>https://orcid.org/0000-0003-4342-6688</orcidid></search><sort><creationdate>202306</creationdate><title>Bauhinia forficata link extract attenuates insulin resistance by preserving glucose uptake in gastrocnemius muscle</title><author>Gasparini, Patricia ; 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Link (Bf extract) hold therapeutic potential for type 2 diabetes mellitus (T2DM) but the mechanism remains poorly understood. This study aimed to test the extract from Bf leaves obtained by decoction on the prevention of T2DM
. The Bf extract was tested on a streptozotocin-induced T2DM mouse model fed on a high-fat diet. The insulin resistance was attenuated in T2DM animals supplemented with Bf extract, which indicates glucose intolerance reduction and p-AKT/AKT ratio preservation in the
muscle. These observations suggested that Bf extract enhanced glucose uptake. Nevertheless, there was no preservation in β-cell insulin secretion in Bf extract-treated T2DM mice. Interestingly, the Bf extract reduced body weight gain without affecting total energy intake. Hence, Bf extract has a hypoglycemic effect which could attenuate the development of insulin resistance.</abstract><cop>England</cop><pub>Taylor & Francis Ltd</pub><pmid>35997243</pmid><doi>10.1080/14786419.2022.2113875</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-6008-4010</orcidid><orcidid>https://orcid.org/0000-0002-1377-158X</orcidid><orcidid>https://orcid.org/0000-0002-7078-6526</orcidid><orcidid>https://orcid.org/0000-0002-7576-5409</orcidid><orcidid>https://orcid.org/0000-0003-4342-6688</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | AKT protein Animals Attenuation Bauhinia Beta cells Bioactive compounds Blood Glucose - metabolism Body weight Body weight gain Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - drug therapy Energy intake Gastrocnemius muscle Glucose Glucose tolerance High fat diet Hypoglycemic Agents In vivo methods and tests Insulin Insulin Resistance Insulin secretion Intolerance Metabolites Mice Muscle, Skeletal - metabolism Muscles Preservation Proto-Oncogene Proteins c-akt Streptozocin Weight reduction |
| title | Bauhinia forficata link extract attenuates insulin resistance by preserving glucose uptake in gastrocnemius muscle |
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