Exploring the role of systemic immune‐inflammation index and neutrophil‐lymphocyte ratio in cardiovascular risk stratification for patients with hidradenitis suppurativa: A cross‐sectional study

Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicle that has previously been associated with a higher cardiovascular risk (CVR). Although different methods have been described for CVR stratification in HS, there is little evidence about the role of hemogram indexes i...

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Bibliographic Details
Published in:Journal of dermatology 2022-12, Vol.49 (12), p.1238-1244
Main Authors: Sánchez‐Díaz, Manuel, Salvador‐Rodríguez, Luis, Cuenca‐Barrales, Carlos, Arias‐Santiago, Salvador, Molina‐Leyva, Alejandro
Format: Article
Language:English
Subjects:
Blood pressure
Body mass index
Cardiovascular diseases
cardiovascular risk
Cross-sectional studies
hidradenitis suppurativa
Hypertension
Inflammatory diseases
Insulin
Insulin resistance
intima‐media thickness
Leukocytes (neutrophilic)
Lymphocytes
Metabolic syndrome
Multivariate analysis
Neutrophils
neutrophil‐lymphocyte ratio
Patients
systemic immune‐inflammation index
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Summary:Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicle that has previously been associated with a higher cardiovascular risk (CVR). Although different methods have been described for CVR stratification in HS, there is little evidence about the role of hemogram indexes in CVR in HS. Given its potential convenience, the aim of this study was to assess the role of the hemogram indexes systemic immune‐inflammation index (SII) and neutrophil‐lymphocyte ratio (NLR) in CVR stratification for patients with HS. A cross‐sectional study was performed to assess the role of SII and NLR in CVR stratification in patients with moderate to severe HS who were candidates for biologic therapy. SII, NLR, carotid intima‐media thickness, and other clinical and biochemical CVR factors were assessed before the start of the treatment. Fifty patients were included. The male:female ratio was 3:2, and the mean International Hidradenitis Suppurativa Severity Score System score was 21.6. After multivariate analysis, SII correlated with higher values of systolic blood pressure, metabolic syndrome, and higher risk of insulin resistance (p 
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.16558