Facile synthesis of boric acid-functionalized magnetic covalent organic frameworks and application to magnetic solid-phase extraction of trace endocrine disrupting compounds from meat samples

• Published in: Food chemistry 2023-01, Vol.399, p.133843-133843, Article 133843
• Main Authors: Liu, Jin, Su, Zhuoqun, Xu, Qinfeng, Shi, Yiheng, Wu, Di, Li, Lin, Wu, Yongning, Li, Guoliang
• Format: Article
• Language: English
• Subjects: Covalent organic frameworks; Endocrine disrupting compounds; Enrichment; HPLC-MS/MS; Magnetic solid-phase extraction
• ISSN: 0308-8146; 1873-7072
• DOI: 10.1016/j.foodchem.2022.133843

[Display omitted] •A boric acid-functionalized magnetic covalent organic framework nanocomposite (Fe3O4@COF@BA) was prepared as adsorbent for the enrichment of EDCs.•The satisfactory recoveries were ranged from 88.8 to 104.2 % with low limits of detection in the range of 0.08–0.72 μg kg−1 for EDCs.•The presented MSPE-HPLC-MS/MS method pays a new avenue on the extraction and determination of EDCs from other complex matrices. A facile approach was proposed for the preparation of boric acid-functionalized core–shell structured magnetic covalent organic framework (COF) nanocomposites through employing the Fe3O4 nanoparticles as magnetic core, boric acid-functionalized COFs as the shell via sequential post-synthetic modification (denoted as Fe3O4@COF@BA). The synthesized nanocomposites showed large specific surface area, high magnetic responsiveness, and desirable chemical and thermal stability. Combined with HPLC-MS/MS, the as-prepared Fe3O4@COF@BA composite was applied as a sorbent for magnetic solid-phase extraction (MSPE) of endocrine disrupting compounds (EDCs) from meat samples. Under optimal conditions, the method displays low limits of detection (LODs, 0.08–0.72 μg kg−1) and good precision with relative standard deviations (RSD) lower than 5.4 %. The approach was successfully employed for the extraction and detection of EDCs in blank and spiked beef, chicken and pork samples with recovery ranging from 88.8 to 104.2 %.