CXCR3 isoform A promotes head and neck cancer progression by enhancing stem‐like property and chemoresistance

Background The chemokine network orchestrates the cancer stem‐like property and consequently participates in cancer progression. CXCR3 contributes cancer progressive property and immunomodulation in the tumor microenvironment. The two major isoforms of CXCR3 are scrutinized and the divergence is sho...

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Bibliographic Details
Published in:Journal of oral pathology & medicine 2022-10, Vol.51 (9), p.791-800
Main Authors: Sun, Wan‐Hsuan, Peng, Ta‐Jung, Tang, Shye‐Jye, Lin, Jo‐Yu, Wang, Chia‐Yi, Fang, Hsueh‐Jou, Sun, Kuang‐Hui
Format: Article
Language:English
Subjects:
Chemokines
Chemoresistance
CXCR3
CXCR3 protein
Head & neck cancer
head and neck cancer
Immunohistochemistry
Immunomodulation
Isoforms
Lymph nodes
Metastases
Oral cancer
Oral cavity
Sox2
Squamous cell carcinoma
Tumor microenvironment
Tumors
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Summary:Background The chemokine network orchestrates the cancer stem‐like property and consequently participates in cancer progression. CXCR3 contributes cancer progressive property and immunomodulation in the tumor microenvironment. The two major isoforms of CXCR3 are scrutinized and the divergence is showed that CXCR3A promotes cancer cell growth and motility while CXCR3B functions contrarily in many studies. However, rare studies illustrate the role of CXCR3 isoforms in cancer stem‐like property and chemoresistance, especially in head and neck cancer (HNC). Methods Levels of CXCR3, CXCR3B, and Sox2 were determined in HNC tissue microarray by immunohistochemistry staining to explore potential clinical relevance. Lentivirus‐mediated CXCR3‐isoform overexpression with MTS assay, clonogenic assay, transwell migration, sphere formation, and chemo‐drug susceptibility were implemented to investigate the role of CXCR3‐isofoms in HNC. Results High levels of CXCR3 were significantly associated with advanced stage (p 
ISSN:0904-2512
1600-0714
DOI:10.1111/jop.13346