Zebrafish sirt5 Negatively Regulates Antiviral Innate Immunity by Attenuating Phosphorylation and Ubiquitination of mavs

The signaling adaptor MAVS is a critical determinant in retinoic acid-inducible gene 1-like receptor signaling, and its activation is tightly controlled by multiple mechanisms in response to viral infection, including phosphorylation and ubiquitination. In this article, we demonstrate that zebrafish...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2022-09, Vol.209 (6), p.1165-1172
Main Authors: Chen, Xiaoyun, Fan, Sijia, Zhu, Chunchun, Liao, Qian, Tang, Jinhua, Yu, Guangqing, Cai, Xiaolian, Ouyang, Gang, Xiao, Wuhan, Liu, Xing
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - genetics
Adaptor Proteins, Signal Transducing - metabolism
Animals
Immunity, Innate
Phosphorylation
Rhabdoviridae
Sirtuins - metabolism
Tretinoin - metabolism
Ubiquitination
Zebrafish - metabolism
Zebrafish Proteins - genetics
Zebrafish Proteins - metabolism
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Summary:The signaling adaptor MAVS is a critical determinant in retinoic acid-inducible gene 1-like receptor signaling, and its activation is tightly controlled by multiple mechanisms in response to viral infection, including phosphorylation and ubiquitination. In this article, we demonstrate that zebrafish , one of the sirtuin family proteins, negatively regulates mavs-mediated antiviral innate immunity. is induced by spring viremia of carp virus (SVCV) infection and binds to mavs, resulting in attenuating phosphorylation and ubiquitination of mavs. Disruption of in zebrafish promotes survival ratio after challenge with SVCV. Consistently, the antiviral responsive genes are enhanced, and the replication of SVCV is diminished in -dificient zebrafish. Therefore, we reveal a function of zebrafish in the negative regulation of antiviral innate immunity by targeting mavs.
ISSN:0022-1767
1550-6606
1550-6606
DOI:10.4049/jimmunol.2100983