Ana o 3 sIgE and diagnostic algorithms reduce cost of cashew allergy diagnosis in children compared with skin prick test: A cost comparison analysis

Background In the absence of a clear clinical history of reaction, diagnosis of cashew allergy using skin prick tests (SPT) or cashew‐specific IgE requires a high number of oral food challenges (OFC). By using Ana o 3 sIgE alone, or a two‐step diagnostic algorithm using cashew sIgE followed by Ana o...

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Published in:Pediatric allergy and immunology 2022-08, Vol.33 (8), p.n/a
Main Authors: Brettig, Tim, Dalziel, Kim, Koplin, Jennifer J., Dang, Thanh, Lange, Lars, McWilliam, Vicki, Sato, Sakura, Savvatianos, Savvas, Perrett, Kirsten P.
Format: Article
Language:English
Subjects:
Algorithms
Allergies
Ana o 3
Anacardiaceae
cashew
cost
Diagnosis
Epinephrine
Immunoglobulin E
Medical diagnosis
Patients
skin prick test
Skin tests
specific IgE
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Summary:Background In the absence of a clear clinical history of reaction, diagnosis of cashew allergy using skin prick tests (SPT) or cashew‐specific IgE requires a high number of oral food challenges (OFC). By using Ana o 3 sIgE alone, or a two‐step diagnostic algorithm using cashew sIgE followed by Ana o 3 sIgE, there is a reduced need for OFC. We aimed to perform a cost comparison for both of these approaches compared with cashew SPT alone. Methods Pooled individual‐level data from 6 studies were used to determine diagnostic accuracy and OFC rate. Two studies used cashew SPT (n = 567, 198 allergic), with 95% positive and negative predictive values of ≥12 mm and
ISSN:0905-6157
1399-3038
DOI:10.1111/pai.13839