In vivo biocompatibility and mechanical study of novel bone

Two epoxy materials with or without adhesively bonded hydroxyapatite (HA) coatings were studied for their biocompatibility and mechanical pushout strength using in vivo implantation in the rabbit lower femur for a duration of 10 days to 6 months. Polymethyl methacrylate (PMMA) and conventionally HA-...

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Bibliographic Details
Published in:Journal of biomedical materials research 1999-08, Vol.46 (2), p.279-286
Main Authors: Revell, P A, Zhang, X S, Evans, S L, Tuke, M A, Gregson, P J
Format: Article
Language:English
Online Access:Get full text
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Summary:Two epoxy materials with or without adhesively bonded hydroxyapatite (HA) coatings were studied for their biocompatibility and mechanical pushout strength using in vivo implantation in the rabbit lower femur for a duration of 10 days to 6 months. Polymethyl methacrylate (PMMA) and conventionally HA-coated titanium alloy (Ti-6Al-4V) were used as control materials. In the biological study, different fluorescent dyes were used to label newly formed bone. The study indicated that the adhesively bonded HA-coated novel epoxy materials were superior to conventional plasma-sprayed Ti-6Al-4V implants with respect to both BMR and bone integration with the implant surfaces. Adhesively bonded HA-coated epoxy materials had similar ISS values to HA-coated Ti-6Al-4V, but the former failed within the bone and coating, while the latter showed splitting between coating and metal. (ISS: interfacial shear strength; BMR: bone mineralization rate.)
ISSN:0021-9304